Cell TransplantationUmbilical cord blood stem cell transplant may help lung, heart disorders
Two studies published in Cell Transplantation investigating the use of human umbilical cord blood stem cell (UCB) transplants for lung and heart disorders in animal models found beneficial results. When human UCB-derived mensenchymal cells were transplanted into newborn laboratory rats with induced oxygen-deprived injury, the effects of the injury lessened. A second study found that UCB mononuclear cells transplanted into sheep with a right ventricular malfunction beneficially altered the malfunction and enhanced diastolic function.
Korea Research Foundation, Medipost Research InstituteContact: Won Soon Park
wonspark@skku.edu
Cell Transplantation Center of Excellence for Aging and Brain Repair
Nature NeuroscienceUpending textbook science on Alzheimer's disease
In a new study published in Nature Neuroscience, Dr. Inna Slutsky of Tel Aviv University's Sackler Faculty of Medicine finds that the amyloid-beta protein, currently the target of Alzheimer's drug research, is essential for normal information transfer through nerve cell networks in the brain. "If this protein is removed from the brain," says Dr. Slutsky, "it may cause an impairment of neuronal function, as well as a further and faster accumulation of amyloid-beta in Alzheimer's."
Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Nature MedicineNew understanding about mechanism for cell death after stroke leads to possible therapy
Scientists at the Brain Research Centre, a partnership of the University of British Columbia Faculty of Medicine and Vancouver Coastal Health Research Institute, have uncovered new information about the mechanism by which brain cells die following a stroke, as well as a possible way to mitigate that damage. The results of the study were recently published online in Nature Medicine.
Contact: Melissa Ashman
mashman@brain.ubc.ca
604-827-3396
University of British Columbia
NatureCancer metabolism discovery uncovers new role of IDH1 gene mutation in brain cancer
Agios Pharmaceuticals scientists have established, for the first time, that the mutated IDH1 gene has a novel enzyme activity consistent with a cancer-causing gene, or oncogene. The mutated form of IDH1 produces a metabolite, 2-hydroxyglutarate, which may contribute to the formation and malignant progression of gliomas, the most common type of brain cancers, through altered metabolic activity. This discovery appears to reverse the previously held belief that IDH1 was non functional for cancer-causing activity.
Agios PharmaceuticalsContact: Kathryn Morris
kathryn@kmorrispr.com
845-635-9828
Yates Public Relations
Journal of NeurophysiologyDrug studied as possible treatment for spinal injuries
Researchers have shown how an experimental drug might restore the function of nerves damaged in spinal cord injuries by preventing short circuits caused when tiny "potassium channels" in the fibers are exposed.
National Institutes of Health, Purdue Research FoundationContact: Emil Venere
venere@purdue.edu
765-494-4709
Purdue University
Source - Science Daily:
Adult Cell Self-Renewal Without Stem Cells?
November 23, 2009 — Is the indefinite self-renewal of adult cells possible without recourse to stem cell intermediates? Scientists have shown that it is possible, by achieving the ex vivo regeneration of macrophages, ...
http://www.sciencedaily.com/releases/2009/11/091116103838.htm
Bladder Cancer Risks Increase Over Time for Smokers
November 23, 2009 — Risk of bladder cancer for smokers has increased since the mid-1990s, with a risk progressively increasing to a level five times higher among current smokers in
http://www.sciencedaily.com/releases/2009/11/091116163208.htm
How Does Embryo's Pancreas 'Know' Which Cells Are to Produce Insulin?
November 23, 2009 — How does the developing pancreas in an embryo 'know' which cells are to produce insulin and which cells are to have other assignments? Researchers need to understand this if they want to be able to ...http://www.sciencedaily.com/releases/2009/11/091113174802.htm
New Cancer Target for Non-Hodgkin's Lymphoma
November 23, 2009 — Physician-scientists have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma, a type of cancer that affects lymphocytes, or white ...
http://www.sciencedaily.com/releases/2009/11/091122161753.htm
New Research Shows Versatility of Amniotic Fluid Stem Cells
November 23, 2009 — For the first time, scientists have demonstrated that stem cells found in amniotic fluid meet an important test of potential to become specialized cell types, which suggests they may be useful for ...
http://www.sciencedaily.com/releases/2009/11/091123083658.htm
Laser Therapy Can Aggravate Skin Cancer, Study Finds
November 20, 2009 — High irradiances of low-level laser therapy should not be used over melanomas. Researchers studied the pain relieving, anti-inflammatory "cold laser," finding that it caused increased tumor growth in ...
http://www.sciencedaily.com/releases/2009/11/091119193805.htm
First Reconstitution of an Epidermis from Human Embryonic Stem Cells
November 20, 2009 — Researchers in
http://www.sciencedaily.com/releases/2009/11/091119193811.htm
November 20, 2009 — Short-term follow-up is a reasonable alternative to invasive biopsy of palpable (capable of being touched or felt) breast lesions with benign imaging features, particularly in younger women with ...
http://www.sciencedaily.com/releases/2009/11/091120111551.htm
New Mechanism Identified for Beneficial Effects of Aspirin in Cardiovascular Disease
November 19, 2009 — New data in humans shows that all doses of aspirin used in clinical practice increase nitric oxide. Nitric oxide is released from the blood vessel wall and may decrease the development and ...
http://www.sciencedaily.com/releases/2009/11/091116205246.htm
Drug Approvals Taking as Long as Ever, Despite New Information Technology at FDA
November 19, 2009 — Drug approvals are taking just as long as they ever did despite increased expenditure on new information technology at the Food and drug Administration. So says a statistical analysis of approval ...
http://www.sciencedaily.com/releases/2009/11/091119101044.htm
Health Highlights: Nov. 23, 2009
- NFL May Change Concussion Policy
- Health Care Reform Bill Moves to Senate Floor for Debate
- Trial of Embryonic Stem Cell Therapy for Eye Disease Planned
Quick Saliva Test May One Day Diagnose Diseases
Age-related protein changes offer clues to treatment advances, study finds
Clinical Trials Update: Nov. 23, 2009
- Psoriasis
- High Blood Pressure
- Bipolar Disorder
Clinical Trials Update: Nov. 20, 2009
- H1N1 Flu Vaccine
- Atrial Fibrillation
- Rheumatoid Arthritis (RA)
PALO ALTO, Calif.----StemCells, Inc. announced today that it has commenced patient recruitment for a Phase I clinical trial designed to test the safety and preliminary efficacy of its HuCNS-SC� purified human neural stem cells in Pelizaeus-Merzbacher Disease , a neurological disorder that primarily afflicts children.
Dendreon's Provenge gets FDA review date - AP - Fri Nov 20
Biotechnology company Dendreon Corp. said Friday the Food and Drug Administration will make a regulatory decision on the potential prostate cancer vaccine Provenge by May 1.
Shedding light on how the brain works
Now, by using gene therapy to insert light-sensitive proteins from algae and other organisms into brain cells, scientists are able to control specific brain ...
H1N1 pandemic highlights world health emergency vulnerabilities
Ethiopian Review
... something not as bad as H5N1, would your government have felt that it could say, let's broker a deal and give away 10 percent of our vaccine in wartime? ...
Opiate Painkillers May Encourage Spread Of Cancer
New research from the
http://www.medicalnewstoday.com/articles/171900.php
Researchers Identify Role Of Gene In Tumor Development
http://www.medicalnewstoday.com/articles/171756.php
Stopping Tissue Stiffening Is Key To Preventing Aggressive Cancers
Scientists have identified an enzyme that is crucial for turning abnormal but non-malignant breast tissue into tumours, according to a study published today in Cell online. Blocking the enzyme lysyl oxidase (LOX) reduced the chance a tumour would form, and also meant tumours that did develop were smaller and less aggressive.
http://www.medicalnewstoday.com/articles/171678.php
Potential Strategy To Help Generate HIV-Neutralizing Antibodies
WHAT: New discoveries about anti-HIV antibodies may bring researchers a step closer to creating an effective HIV vaccine, according to a new paper co-authored by scientists at the
http://www.medicalnewstoday.com/articles/171716.php
Cancers' Sweet Tooth May Be Weakness
The pedal-to-the-metal signals driving the growth of several types of cancer cells lead to a common switch governing the use of glucose, researchers at Winship Cancer Institute of Emory University have discovered. Scientists who study cancer have known for decades that cancer cells tend to consume more glucose, or blood sugar, than healthy cells. This tendency is known as the "Warburg effect," honoring discoverer Otto Warburg, a German biochemist who won the 1931 Nobel Prize in Medicine. Now a Winship-led team has identified a way to possibly exploit cancer cells' taste for glucose.
http://www.medicalnewstoday.com/articles/171556.php
Potential Treatment for Down Syndrome
http://www.technologyreview.com/biomedicine/23979/
Enhancing Access to Genomic Medicine
http://www.technologyreview.com/business/23997/
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