Wednesday, November 4, 2009

GBP Health / Biotech News 10-28-2009


Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ <http://www.gbpcap.com/> . Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.



Source - EurekAlert – Biology:


Public Release: 28-Oct-2009
Journal of American Chemical Society
Next-generation microcapsules deliver 'chemicals on demand' <http://www.eurekalert.org/pub_releases/2009-10/acs-nmd102809.php>
Scientists in California are reporting development of a new generation of the microcapsules used in carbon-free copy paper, in which capsules burst and release ink with pressure from a pen. The new microcapsules burst when exposed to light, releasing their contents in ways that could have wide-ranging commercial uses from home and personal care to medicine.Their study appears in the Journal of the American Chemical Society, a weekly publication.
Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society <http://www.acs.org>



Public Release: 27-Oct-2009
UT Southwestern patient first in North Texas to receive newest-generation heart failure device <http://www.utsouthwestern.edu/utsw/cda/dept353744/files/559637.html>
UT Southwestern Medical Center patient Michael LeBlanc, 40, is the first in North Texas to receive the newest generation of a mechanical device designed to improve heart function. It will be his lifeline while he awaits a heart transplant.
Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center <http://www.swmed.edu>



Public Release: 26-Oct-2009
Physical Review Letters
Slipper-shaped blood cells <http://www.eurekalert.org/pub_releases/2009-10/aps-sbc102609.php>
Physicists investigate the forces that deform red blood cells into asymmetric slipper shapes, and strive to learn how the deformation is important in blood flow and various blood flow-related diseases.
Contact: James Riordon
riordon@aps.org
301-209-3238
American Physical Society <http://www.aps.org>



Public Release: 23-Oct-2009
Experimental Biology and Medicine
Concurrent imaging of metabolic and electric signals in the heart <http://www.eurekalert.org/pub_releases/2009-10/sfeb-ci102309.php>
Cardiac rhythm disorders can result from disturbances in cardiac metabolism. These metabolic changes are tightly linked with specific cardiac electrophysiology abnormalities -- such as depressed excitability, impaired intra- and extracellular conductivities, wave propagation block and alteration of conduction velocity -- action potential amplitude, and duration. The altered electrophysiology eventually can lead to arrhythmias, fibrillation and cardiac death; therefore, understanding the spatiotemporal complexity of the relationship between metabolism and electrophysiology is the challenge in developing new approaches for treatment of cardiac diseases.
National Institutes of Health, Vanderbilt Institute for Integrative Biosystems Research and Education, American Heart Association, Simons Center for Systems Biology
Contact: Veniamin Y. Sidorov
v.sidorov@vanderbilt.edu
615-322-4419
Society for Experimental Biology and Medicine <http://www.sebm.org/>



Public Release: 22-Oct-2009
Proceedings of the National Academy of Sciences
Boston University scientists first to see RNA network in live bacterial cells <http://www.eurekalert.org/pub_releases/2009-10/bu-bus102209.php>
New technology has given BU scientists the first look ever at RNA in a live bacteria cell -- a sight that could offer new information about how the molecule moves and works.
Contact: Natasha E. Broude, Ph.D
nebroude@bu.edu
617-358-4367
Boston University <http://www.bu.edu>



Public Release: 22-Oct-2009
Nano Letters
Nanowire biocompatibility in the brain: So far so good <http://www.eurekalert.org/pub_releases/2009-10/src-nbi102209.php>
Scientists at Lund University have investigated this "worst case" by injecting nanowires in rat brains. The nanowires resemble in size and shape the registration nodes of electrodes of the future. The results show that the brain "clean-up cells," take care of the wires. After 12 weeks only minor differences were observed between the brains of the test group and the control group. The findings are published in Nano Letters.
Contact: Kristina Lindgarde
kristina.lindgarde@kansli.lth.se
Swedish Research Council <http://www.vr.se>



Public Release: 22-Oct-2009
Sensor biochips could aid in cancer diagnosis and treatment <http://www.eurekalert.org/pub_releases/2009-10/tum-sbc102109.php>
Researchers at TUM, the Technische Universitaet Muenchen, have developed a new test process -- using lab-on-a-chip technology -- for establishing whether or not a cancer patient's tumor cells will respond to a particular drug. Such sensor biochips could potentially be used in the future to aid in rapid identification of the most effective medication for individual patients.
Contact: Markus Bernards
presse@zv.tum.de
49-892-892-2562
Technische Universitaet Muenchen <http://www.tum.de>


Source - Science Daily:

Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.

Scientists Use World's Fastest Supercomputer To Create The Largest HIV Evolutionary Tree <http://www.sciencedaily.com/releases/2009/10/091027161536.htm>
October 28, 2009 — In a new study the evolutionary history of more than 10,000 sequences from more than 400 HIV-infected individuals was compared. The idea is to identify common features of the transmitted virus, and ...
http://www.sciencedaily.com/releases/2009/10/091027161536.htm

Does Diabetes Speed Up Memory Loss In Alzheimer's Disease? <http://www.sciencedaily.com/releases/2009/10/091027161521.htm>
October 28, 2009 — Research has shown that diabetes increases the risk of Alzheimer's disease and the risk of memory loss in people who don't have Alzheimer's disease. But it hasn't been clear whether people with ...
http://www.sciencedaily.com/releases/2009/10/091027161521.htm

Common Weed Could Provide Clues On Aging And Cancer <http://www.sciencedaily.com/releases/2009/10/091026162538.htm>
October 28, 2009 — A common weed and human cancer cells could provide some very uncommon details about DNA structure and its relationship with telomeres and how they affect cellular aging and cancer, according to ...
http://www.sciencedaily.com/releases/2009/10/091026162538.htm

Combination Antiretroviral Therapy Effective At Reducing HIV Resistance In Mothers And Babies Following Mother-to-child Transmission <http://www.sciencedaily.com/releases/2009/10/091026220007.htm>
October 28, 2009 — In a clinical trial investigating mother-to-child HIV transmission in South Africa researchers find that adding two other antiretroviral drugs to single dose nevirapine -- an antiretroviral drug ...
http://www.sciencedaily.com/releases/2009/10/091026220007.htm

Nervous System Drug-by-design: Formulation May Slow Parkinson's, Alzheimer's, Huntington's <http://www.sciencedaily.com/releases/2009/10/091026125537.htm>
October 28, 2009 — A researcher in Israel is "building" a new drug, L803-MTS, to treat a number of central nervous system diseases, and it also shows promise against Parkinson's, Huntington's and ...
http://www.sciencedaily.com/releases/2009/10/091026125537.htm

Location Of Body Fat Affects Risk Of Blood Clots In Men, Women <http://www.sciencedaily.com/releases/2009/10/091026162535.htm>
October 28, 2009 — The risk of life-threatening blood clots increases with obesity, but may also depend on the location of excess body fat and gender. Women are at higher risk when they carry extra pounds on their ...
http://www.sciencedaily.com/releases/2009/10/091026162535.htm

Smoking Gun: Just One Cigarette Has Harmful Effect On Arteries Of Young Healthy Adults <http://www.sciencedaily.com/releases/2009/10/091027085300.htm>
October 27, 2009 — Even one cigarette has serious adverse effects on young adults, according to new ...
http://www.sciencedaily.com/releases/2009/10/091027085300.htm

Scientists Discover Gene That 'Cancer-proofs' Naked Mole Rat's Cells <http://www.sciencedaily.com/releases/2009/10/091026152812.htm>
October 27, 2009 — Despite a 30-year lifespan that gives ample time for cells to grow cancerous, a small rodent species called a naked mole rat has never been found with tumors of any kind -- and now biologists think ...
http://www.sciencedaily.com/releases/2009/10/091026152812.htm

Holocaust Survivors At Higher Risk For All Cancers <http://www.sciencedaily.com/releases/2009/10/091026161840.htm>
October 27, 2009 — Jewish survivors of World War II who were potentially exposed to the Holocaust are at a higher risk for cancer occurrence, according to a new ...
http://www.sciencedaily.com/releases/2009/10/091026161840.htm
Link Between Alcohol And Cancer Explained: Alcohol Activates Cellular Changes That Make Tumor Cells Spread <http://www.sciencedaily.com/releases/2009/10/091026172052.htm>
October 27, 2009 — Alcohol consumption has long been linked to cancer and its spread, but the underlying mechanism has never been clear. Now, researchers have identified a cellular pathway that may explain the ...
http://www.sciencedaily.com/releases/2009/10/091026172052.htm

Adding Tools Against Breast Tumors <http://www.sciencedaily.com/releases/2009/10/091027103111.htm>
October 27, 2009 — At the end of a 10-year, coast-to-coast study of women with an unusual form of breast cancer, medical researchers are making the case for a particular combination of treatments to stop the tumors in ...
http://www.sciencedaily.com/releases/2009/10/091027103111.htm

Study Finds Best Use Of Insulin As Diabetes Progresses <http://www.sciencedaily.com/releases/2009/10/091025205419.htm>
October 26, 2009 — A large-scale trial in diabetes patients has provided new evidence on how best to add insulin to standard drugs to control blood sugar levels as type 2 diabetes ...
http://www.sciencedaily.com/releases/2009/10/091025205419.htm

Sperm May Play Leading Role In Spreading HIV <http://www.sciencedaily.com/releases/2009/10/091026093715.htm>
October 26, 2009 — Sperm, and not just the fluid it bathes in, can transmit HIV to macrophages, T cells, and dendritic cells (DCs), researchers report. By infecting DCs, which carry the virus and potently pass it to T ...
http://www.sciencedaily.com/releases/2009/10/091026093715.htm

Latest Diabetes Figures Paint Grim Global Picture <http://www.sciencedaily.com/releases/2009/10/091020094058.htm>
October 26, 2009 — New data shows that a staggering 285 million people worldwide have diabetes. The latest figures from the IDF Diabetes Atlas indicate that people in low and middle-income countries are bearing the ...
http://www.sciencedaily.com/releases/2009/10/091020094058.htm

Alternatively Spliced Tissue Factor Identified As Promising New Biomarker For Aggressive Cancers <http://www.sciencedaily.com/releases/2009/10/091026152936.htm>
October 26, 2009 — A recently discovered form of the protein that triggers blood clotting may play a key role in the molecular mechanisms leading to the growth of certain metastatic cancers, according to new ...
http://www.sciencedaily.com/releases/2009/10/091026152936.htm

First National And Evidence-based Guidelines For Brain Cancer Released <http://www.sciencedaily.com/releases/2009/10/091026152808.htm>
October 26, 2009 — The first national treatment guidelines for brain metastases, which account for nearly 500,000 new cancers annually in the United States, were recently released. The guidelines were developed by a ...
http://www.sciencedaily.com/releases/2009/10/091026152808.htm

Protein Critical For Insulin Secretion May Be Contributor To Diabetes <http://www.sciencedaily.com/releases/2009/10/091026125541.htm>
October 26, 2009 — A cellular protein from a family involved in several human diseases is crucial for the proper production and release of insulin, new research has found, suggesting that the protein might play a role ...
http://www.sciencedaily.com/releases/2009/10/091026125541.htm

Angina In The Legs? Time To Alert Patients And Physicians <http://www.sciencedaily.com/releases/2009/10/091026093223.htm>
October 26, 2009 — Researchers recommend that people over age 40 be screened for peripheral artery disease (PAD), which puts people at high risk for serious medical complications including heart disease, stroke and ...
http://www.sciencedaily.com/releases/2009/10/091026093223.htm

Seeing Previously Invisible Molecules For The First Time <http://www.sciencedaily.com/releases/2009/10/091023104704.htm>
October 24, 2009 — Chemists have developed a new microscopic technique for seeing, in color, molecules with undetectable fluorescence. The room-temperature technique allows researchers to identify previously unseen ...
http://www.sciencedaily.com/releases/2009/10/091023104704.htm

Alzheimer's Lesions Found In The Retina <http://www.sciencedaily.com/releases/2009/10/091021125139.htm>
October 22, 2009 — The eyes may be the windows to the soul, but new research indicates they also may mirror a brain ravaged by Alzheimer's ...
http://www.sciencedaily.com/releases/2009/10/091021125139.htm


Source - Health Day:

Health Highlights: Oct. 28, 2009 <http://www.healthday.com/Article.asp?AID=632517>
  • NFL Offers Support To Former Players With Dementia
  • Curry Spice Chemical Kills Esophageal Cancer Cells: Study
  • Radiation Treatment Required For Fresh Gulf of Mexico Oysters
  • Enzyme May Be Key in Nerve Fiber Regeneration
  • Cars Big Threat To Trick-or-Treaters
More Swine Flu Vaccine Coming Soon
22 million doses out now, and shortage should ease over coming weeks, CDC says.
Clinical Trials Update: Oct. 28, 2009 <http://www.healthday.com/Article.asp?AID=632516>
  • COPD (Chronic Obstructive Pulmonary Disease)
  • Congestive Heart Failure (CHF)
  • Cold Sores
Radiation From Medical Scans Soaring <http://www.healthday.com/Article.asp?AID=632420>
Americans now get 6-fold more exposure than in 1980, researchers say

Clinical Trials Update: Oct. 27, 2009 <http://www.healthday.com/Article.asp?AID=632460>
  • High Blood Pressure
  • Attention Deficit Hyperactivity Disorder (ADHD)
  • Overactive Bladder (Ages 65+)
Clinical Trials Update: Oct. 26, 2009 <http://www.healthday.com/Article.asp?AID=632399>
  • High Cholesterol
  • Type 2 Diabetes
  • Irritable Bowel Syndrome (IBS) with Constipation
Clinical Trials Update: Oct. 23, 2009 <http://www.healthday.com/Article.asp?AID=632333>
  • Ragweed Allergy
  • Atrial Fibrillation
  • Psoriasis
Clinical Trials Update: Oct. 22, 2009 <http://www.healthday.com/Article.asp?AID=632279>
  • Alzheimer's Disease
  • Asthma
  • Restless Legs Syndrome



Source - Yahoo Biotech News:


Novavax and CPL Biologicals Break Ground on New Influenza Vaccine Manufacturing Facility in India <http://us.rd.yahoo.com/finance/industry/news/mostpop/*http:/biz.yahoo.com/prnews/091028/ph00427.html?.v=1> - PR Newswire - Wed 8:04 am ET
Novavax, Inc. announced today that CPL Biologicals Pvt. Ltd., the new joint venture between Cadila Pharmaceuticals in India, has begun construction of a state-of-the-art manufacturing facility that will be used to produce pandemic and seasonal influenza vaccines.

HGSI Drug under FDA Review <http://us.rd.yahoo.com/finance/industry/news/mostpop/*http:/biz.yahoo.com/zacks/091028/26573.html?.v=1> - Zacks.com - 2 hours, 42 minutes ago
The FDA has raised doubts over the efficacy of the drug ABthrax, manufactured by Human Genome Sciences Inc. and meant for treating anthrax infection.



Source - Google Health News:

What's the ideal price for the swine flu vaccine? <http://www.google.com/url?sa=X&q=http://latimesblogs.latimes.com/booster_shots/2009/10/intention-to-get-h1n1-swine-flu-vaccine-.html&ct=ga&cd=G9MzilxkFLk&usg=AFQjCNEh-cfNl-Fbnupv8YOaQ5QNGHkmPw>
Los Angeles Times
The results are based on a survey conducted in Hong Kong, whose recent experience with severe acute respiratory syndrome and H5N1 bird flu arguably give the ...

Push Is on for New Flu Drugs in Pipeline <http://www.google.com/url?sa=X&q=http://abcnews.go.com/Health/wireStory%3Fid%3D8912312&ct=ga&cd=-7-I-T_C9dc&usg=AFQjCNHTKijywkRtxidCweIDV_NB0DK_gw>
ABC News
"In general, I think that the field is looking much more promising than it has in some years and obviously this is in part due to the threats of H5N1 (avian ...

Gene therapy successful on a blindness <http://www.google.com/url?sa=X&q=http://www.philly.com/inquirer/health_science/daily/20091025_Gene_therapy_successful_on_a_blindness.html&ct=ga&cd=fhXpHvmMgwg&usg=AFQjCNHIiiEz4PBK6tB7lwMB9en4vM5TcA>
Philadelphia Inquirer
The results are one of the few successes thus far in the young field of gene therapy, though the pace is starting to accelerate. ...

Minneapolis Optimist program offers desperate heart patients hope <http://www.google.com/url?sa=X&q=http://www.twincities.com/localnews/ci_13655486&ct=ga&cd=fhXpHvmMgwg&usg=AFQjCNE8XhRNDeHk_XInagWDMNhehdMB7Q>
Pioneer Press
Johnson, 69, suffered chest pain for years until he enrolled in a gene therapy clinical trial with Dr. Tim Henry. Now, Johnson says, he has no chest pain. ...



Source - Medical News Today:


Curry Powder Ingredient Kills Cancer Cells <
http://www.medicalnewstoday.com/articles/168987.php>
Researchers from Ireland and Poland found that curcumin, a compound found in the popular Indian spice turmeric that gives curry powder its distinct yellow colour, killed oesophageal cancer <
http://www.medicalnewstoday.com/info/cancer-oncology/whatiscancer.php> cells in the lab via an unexpected cell-death mechanism that did not involve apoptosis or cell suicide. Moreover, they found that the compound started killing cancer cells within 24 hours and the cells began to digest themselves.
http://www.medicalnewstoday.com/articles/168987.php

Liver Removed And Re-Implanted For Cancer Treatment <http://www.medicalnewstoday.com/articles/169010.php>
Distinguished transplant and cancer <
http://www.medicalnewstoday.com/info/cancer-oncology/whatiscancer.php> surgeon, Alan Hemming, MD, has been recruited to the University of California, School of Medicine to launch a multidisciplinary center for the treatment of advanced liver disease at the UC San Diego Medical Center and Moores UCSD Cancer Center. This innovative program is designed to offer adult and pediatric patients in the western United States a single destination for the treatment of complex liver disease, from advanced diagnostics to experimental medical therapies and novel approaches for liver resection and transplantation. "Whether you are suffering from liver failure, or primary or secondary liver malignancy, there are new combinations of treatment that can be delivered to you at UCSD Medical Center," said Hemming, professor of surgery and Chief of Transplantation and Hepatobiliary Surgery. "If you have been told that you have untreatable liver disease, there is hope for you here. As a world-recognized academic medical center, UC San Diego has the expertise, resources and skill to take on the most difficult cases."
http://www.medicalnewstoday.com/articles/169010.php

Six Innovations That Could Prove Critical To Reforming The Health Care System <http://www.medicalnewstoday.com/articles/168961.php>
The Wall Street Journal <
http://online.wsj.com/public/page/health-care-102709.html> offers a collection of stories that looks at changes in health care that could yield big responses: "Health-care innovations come in many shapes and sizes ... [including] the kind that can help reach the goal that continues to elude our policy makers: getting good care to the greatest number of people in the most cost-effective way."

The Journal looks at six innovations including changes in public policy and high technology, hospital procedures and market competition, that improve the doctor-patient relationship. It notes "one of the most promising innovations in the delivery of care isn't a technology or a new device but a simple idea: patient- and family-centered care, an approach that aims to remove the wall between medical professionals and patients, and bring the human touch back to medicine" (Landro, 10/27).

http://www.medicalnewstoday.com/articles/168961.php

Exelixis And Bristol-Myers Squibb Report New Phase 2 Data For XL184 In Patients With The Most Common And Aggressive Form Of Brain Cancer <http://www.medicalnewstoday.com/articles/168701.php>
Exelixis, Inc. (Nasdaq:EXEL) and Bristol-Myers Squibb Company (NYSE:BMY) today reported updated phase 2 clinical data which show that XL184 demonstrated activity in patients with glioblastoma multiforme (GBM), the most common and aggressive form of brain cancer <
http://www.medicalnewstoday.com/info/cancer-oncology/whatiscancer.php> . The data from study XL184-201 were presented today during a poster session at the 2009 Joint Meeting of the Society for Neuro-Oncology and the AANS/CNS Section on Tumors.
http://www.medicalnewstoday.com/articles/168701.php



Source - MIT's Technology Review:


Tiny Devices Use Light to Grab Cells <http://www.technologyreview.com/biomedicine/23791/>
http://www.technologyreview.com/biomedicine/23791/

Awakening Paralyzed Limbs <http://www.technologyreview.com/biomedicine/23790/>
http://www.technologyreview.com/biomedicine/23790/

Delivering a Virus Imposter Quicker <http://www.technologyreview.com/biomedicine/23782/>
http://www.technologyreview.com/biomedicine/23782/

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.