Friday, October 2, 2009

GBP Health / Biotech News 10-02-2009

Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ <http://www.gbpcap.com/> . Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.


Source - EurekAlert – Biology:


Public Release: 1-Oct-2009
Journal of Experimental Medicine
'Natural killer' cells keep immune system in balance <http://news.brown.edu/pressreleases/2009/10/immunity>
Researchers from Brown University and McGill University have discovered that the natural killer, or NK cells, help prevent T cells from over-responding when a virus hits. This balance helps prevent T cells, which ordinarily serve the immune system, from causing harm. Details are in the September issue of the Journal of Experimental Medicine.
National Institutes of Health, Canadian Health Institute
Contact: Mark Hollmer
Mark_Hollmer@brown.edu <mailto:Mark_Hollmer@brown.edu>
401-863-1862
Brown University <http://www.brown.edu/Administration/News_Bureau>

Public Release: 1-Oct-2009
FASEB Journal
You must remember this: Scientists develop nasal spray that improves memory <http://www.eurekalert.org/pub_releases/2009-10/foas-ymr100109.php>
Good news for procrastinating students: a nasal spray developed by scientists promises to give late night cram sessions a major boost, if a good night's sleep follows. In a research report featured as the cover story of the October 2009 print issue of the FASEB Journal, these scientists show that a molecule from the body's immune system (interleukin-6) when administered through the nose helps the brain retain emotional and procedural memories during REM sleep.
Contact: Cody Mooneyhan
cmooneyhan@faseb.org <mailto:cmooneyhan@faseb.org>
301-634-7104
Federation of American Societies for Experimental Biology <http://www.faseb.org>

Public Release: 1-Oct-2009
Cell
Scripps research scientists find missing puzzle piece of powerful DNA repair complex <http://www.eurekalert.org/pub_releases/2009-10/sri-srs093009.php>
Researchers at the Scripps Research Institute have found, crystallized, and biologically characterized a poorly defined component of a key molecular complex that helps people to avoid cancer, but that also helps cancer cells resist chemotherapy.
NIH/National Cancer Institute, DOE/Lawrence Berkeley National Laboratory
Contact: Keith McKeown
kmckeown@scripps.edu <mailto:kmckeown@scripps.edu>
858-784-8134
Scripps Research Institute <http://www.scripps.edu>

Public Release: 1-Oct-2009
Science
Longer-lived, healthier mice offer promise of drug treatments for age-related diseases <http://www.eurekalert.org/pub_releases/2009-10/wt-lhm092909.php>
Scientists have managed to extend the lifespan of mice by up to a fifth and reduce the number of age-related diseases the animals suffer. The research, which involved blocking a key molecular pathway, mimics the health benefits of reducing calorie intake and suggests that drug treatments for aging and age-related diseases are feasible.
Wellcome Trust
Contact: Craig Brierley
c.brierley@wellcome.ac.uk <mailto:c.brierley@wellcome.ac.uk>
44-207-611-7329
Wellcome Trust <http://www.wellcome.ac.uk>

Public Release: 1-Oct-2009
Cell Stem Cell
Umbilical cord blood as a readily available source for off-the-shelf, patient-specific stem cells <http://www.eurekalert.org/pub_releases/2009-10/si-ucb092809.php>
Umbilical cord blood cells can successfully be reprogrammed to function like embryonic stem cells, setting the basis for the creation of a comprehensive bank of tissue-matched, cord blood-derived induced pluripotent stem cells for off-the-shelf applications, report researchers at the Salk Institute for Biological Studies and the Center for Regenerative Medicine in Barcelona, Spain.
Contact: Gina Kirchweger
Kirchweger@salk.edu <mailto:Kirchweger@salk.edu>
858-453-410-01340
Salk Institute <http://www.salk.edu>

Public Release: 1-Oct-2009
Cell Stem Cell
It's in the bank: Human cord blood reprogrammed into embryonic-like stem cells <http://www.eurekalert.org/pub_releases/2009-10/cp-iit092809.php>
Human umbilical cord blood cells may be far more versatile than previous research has indicated. Two independent studies, published by Cell Press in the Oct. 2 issue of the journal Cell Stem Cell, report that they have successfully reprogrammed human umbilical cord blood cells into cells with properties similar to human embryonic stem cells.
Contact: Cathleen Genova
cgenova@cell.com <mailto:cgenova@cell.com>
617-397-2802
Cell Press <http://www.cellpress.com>

Public Release: 29-Sep-2009
Advanced Materials
A step toward better brain implants using conducting polymer nanotubes <http://www.ns.umich.edu/htdocs/releases/story.php?id=7335>
Brain implants that can more clearly record signals from surrounding neurons in rats have been created at the University of Michigan. The findings could eventually lead to more effective treatment of neurological disorders such as Parkinson's disease and paralysis.
US Army Research Office, Center for Neural Communication Technology, National Institutes of Health
Contact: Byron Roberts
byronr@umich.edu <mailto:byronr@umich.edu>
734-647-7085
University of Michigan <http://www.umich-edu.com/>


Source - Science Daily:

Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.

Lung Cancer Risk Increases With Expression Of Specific Genes <http://www.sciencedaily.com/releases/2009/10/091001081211.htm>
October 1, 2009 — A recent study determined that variations of specific genetic markers identified in previous research, or SNPs, may indicate a greater lung cancer risk in African Americans than in whites. The genes ...
http://www.sciencedaily.com/releases/2009/10/091001081211.htm

Molecular Imaging Holds Promise For Early Intervention In Common Uterine Cancer <http://www.sciencedaily.com/releases/2009/10/091001081213.htm>
October 1, 2009
— A promising new molecular imaging technique may provide physicians and patients with a noninvasive way to learn more information about a type of cancer of the uterus lining called "endometrial ...
http://www.sciencedaily.com/releases/2009/10/091001081213.htm

Calcium Scans May Be Effective Screening Tool For Heart Disease <http://www.sciencedaily.com/releases/2009/09/090930102536.htm>
October 1, 2009
— A simple, non-invasive test appears to be an effective screening tool for identifying patients with silent heart disease who are at risk for a heart attack or sudden death. Coronary artery calcium ...
http://www.sciencedaily.com/releases/2009/09/090930102536.htm

New Knowledge About Bone Marrow Transplants Can Help Leukemia Patients <http://www.sciencedaily.com/releases/2009/09/090930102721.htm>
October 1, 2009
— Acute lymphatic leukemia is the most common form of blood cancer in children. Even though chemotherapy is improving, the cancer often returns. New research shows that cancer cells that have been ...
http://www.sciencedaily.com/releases/2009/09/090930102721.htm

Recent, Vigorous Exercise Is Associated With Reduced Breast Cancer Risk <http://www.sciencedaily.com/releases/2009/09/090930194256.htm>
October 1, 2009
— Post-menopausal women who engage in moderate to vigorous exercise have a reduced risk of breast cancer. This comes from researchers who investigated the link between breast cancer and ...
http://www.sciencedaily.com/releases/2009/09/090930194256.htm

New Markers Discovered For Early Detection Of Type 1 Diabetes <http://www.sciencedaily.com/releases/2009/09/090930102723.htm>
October 1, 2009
— Diabetes can be dangerous -- especially when the disease is not diagnosed in time. German scientists have identified new markers which enable an early diagnosis and prognosis of type 1 ...
http://www.sciencedaily.com/releases/2009/09/090930102723.htm

New Approach For The Treatment Of Malignant Brain Tumors <http://www.sciencedaily.com/releases/2009/10/091001091759.htm>
October 1, 2009
— Initial chemotherapy alone after surgery is just as successful as initial radiation therapy for patients from whom a very malignant brain tumor (anaplastic glioma) was removed, a new study has found. ...
http://www.sciencedaily.com/releases/2009/10/091001091759.htm

Potential New Imaging Agent For Early Diagnosis Of Most Serious Skin Cancer <http://www.sciencedaily.com/releases/2009/09/090930112140.htm>
September 30, 2009
— Scientists in Australia are reporting development and testing in laboratory animals of a potential new material for diagnosing malignant melanoma, the most serious form of skin ...
http://www.sciencedaily.com/releases/2009/09/090930112140.htm

New Chemically-activated Antigen Could Expedite Development Of HIV Vaccine <http://www.sciencedaily.com/releases/2009/09/090921143145.htm>
September 30, 2009
— Scientists working to develop a vaccine for the human immunodeficiency virus report they have created the first antigen that induces protective antibodies capable of blocking infection of human cells ...
http://www.sciencedaily.com/releases/2009/09/090921143145.htm



Source - Health Day:


Health Highlights: Oct. 1, 2009 <http://www.healthday.com/Article.asp?AID=631561>
  • Michael Jackson Healthy Before Death: Autopsy Report
  • EPA to Create New Greenhouse Gas Regulations
  • Drug Deaths Outnumber Traffic Fatalities In 16 States: CDC
  • Swine Flu-Related School Closings Could Cost $47 Billion: Report
Heart-Pacing Devices Hold Promise for Heart Failure <http://www.healthday.com/Article.asp?AID=631511>
Defibrillators, pacemakers offer benefits for patients with milder forms of the condition, study suggests
Clinical Trials Update: Oct. 1, 2009 <http://www.healthday.com/Article.asp?AID=631509>
  • Flu Vaccine
  • Head Lice
  • High Blood Pressure (Hypertension)
Breast Cancer Death Rates Continue to Drop 2% Annually <http://www.healthday.com/Article.asp?AID=631462>
But mortality still higher among black women than white women, U.S. report says

Clinical Trials Update: Sept. 30, 2009
  • Osteoarthritis of the Knee
  • Ragweed Allergy
  • Endometriosis


Source - Yahoo Biotech News:


Keryx Cancer Drug Impresses <http://us.rd.yahoo.com/finance/industry/news/mostpop/*http:/biz.yahoo.com/zacks/091001/25388.html?.v=1> - Zacks.com - Thu 10:02 am ET
The candidate demonstrated efficacy, safety and tolerability in metastatic renal cell carcinoma .

Stem Cell Summit Can't Excite Investors <http://us.rd.yahoo.com/finance/industry/news/mostpop/*http:/biz.yahoo.com/indie/090930/2386_id.html?.v=1> - Indie Research - Wed 12:27 pm ET
The 2009 World Stem Cell Summit concluded a week ago, and since then the sector's stocks have slipped into the red.

China doubles order for Sinovac swine flu vaccine <http://us.rd.yahoo.com/finance/industry/news/mostpop/*http:/biz.yahoo.com/ap/090930/us_sinovac_swine_flu.html?.v=1> - AP - Wed 10:44 am ET
Sinovac Biotech Ltd. said Wednesday the Chinese government purchased 3 million more doses of Sinovac's Panflu.1 swine flu vaccine, bringing the total order to 6.3 million doses.


Source - Google Health News:


Researchers: Gene therapy may offer cure for sickle cell disease <http://www.google.com/url?sa=X&q=http://www.smartbrief.com/news/bio/storyDetails.jsp%3Fissueid%3DE57AB49F-44A7-4C21-A506-7B2D73F68771%26copyid%3D4DB2F545-3FBF-45F2-B366-1F6A3B06050D&ct=ga&cd=RASjAe0z_Do&usg=AFQjCNFtgrc25DnhBBYkvPvxYKnBNTxk>
SmartBrief
Researchers have developed a gene therapy for sickle cell anemia that allowed laboratory animals and human tissue samples to produce normal red blood cells ...

ANALYSIS-US big pharma jumps back into flu business <http://www.google.com/url?sa=X&q=http://www.reuters.com/article/latestCrisis/idUSN29410689&ct=ga&cd=UfWrBQFKLL4&usg=AFQjCNG3j4QQ7qr0QTf2cr6ENLUdnld8Lw>
Reuters
Then H5N1 (avian influenza) came along," she said. Ertl said beginning with an outbreak of bird flu in Hong Kong in 1998, the United States and other ...


Source - Medical News Today:


Cardiac Stem Cell Trial Seeks To Treat Some Heart Attack Patients

Researchers at UCSF Medical Center have begun enrollment for an early-stage clinical trial to evaluate the safety and efficacy of an adult stem cell <http://www.medicalnewstoday.com/info/stem_cell/whatarestemcells.php> therapy for patients who have just experienced their first acute myocardial infarction, or heart attack <http://www.medicalnewstoday.com/articles/151444.php> . The trial is part of a multi-center national study. The cells used, known as mesenchymal stem cells, were obtained from the bone marrow of healthy adult donors. Depending on their location in the body, mesenchymal stem cells give rise to bone, cartilage, fat, muscle and connective tissue.

http://www.medicalnewstoday.com/articles/165903.php


Drug Companies Called On To Pool HIV Patents <http://www.medicalnewstoday.com/articles/165849.php>

The international medical humanitarian organization Doctors Without Borders/Médecins Sans Frontières (MSF) today called on nine of the world's largest pharmaceutical companies to help accelerate the availability of new treatments for millions of people living with HIV/AIDS, by pooling their patents on a list of key HIV <http://www.medicalnewstoday.com/articles/17131.php> medicines. A patent pool is a mechanism in which a number of patents held by different parties are brought together and made available to others for production or further development. Patent holders receive royalties paid by those using the patents. The mechanism has been instrumental in promoting innovations in the aeronautics and digital telecommunications industries, for example.

http://www.medicalnewstoday.com/articles/165849.php



FDA Delays Decision On HPV Vaccine Cervarix <http://www.medicalnewstoday.com/articles/165815.php>

FDA for the second time has delayed its decision on British drugmaker GlaxoSmithKline's human papillomavirus vaccine, Cervarix, the Wall Street Journal <http://online.wsj.com/article/SB10001424052748704471504574443370329592880.html> reports. According to the company, FDA did not indicate that the delay was related to reports that a 14-year-old British girl died this week after receiving the vaccine. According to a statement from British health authorities, the girl had an "underlying medical condition" that likely caused her death, and it is "unlikely that the HPV vaccination was the cause of death." The statement added that officials "are awaiting further test results, which will take some time." FDA was scheduled to announce its decision Tuesday but told GSK it would miss the deadline, according to the drugmaker (Whalen, Wall Street Journal, 9/30). FDA does not comment on pending product reviews, an agency spokesperson said (Perrone, AP/Boston Globe <http://www.boston.com/business/healthcare/articles/2009/09/29/fda_delays_ruling_on_glaxo_cervical_cancer_vaccine/> , 9/29).
http://www.medicalnewstoday.com/articles/165815.php


UK Lab Finds New Natural Way To Collect Stem Cells - Through Teeth <http://www.medicalnewstoday.com/articles/165756.php>

Pioneered by BioEDEN, tooth cell banking is a safe, natural and wholly non-invasive method of collecting and preserving precious stem cells <http://www.medicalnewstoday.com/info/stem_cell/whatarestemcells.php> which could hold the key to children's health. BioEDEN, headquartered at Daresbury Science & Innovation Centre near Warrington, is the world's first company to collect, assess and cryogenically store living tooth cells retrieved from children's baby or 'milk' teeth. BioEDEN have laboratories in Warrington, England and Austin Texas, USA.

http://www.medicalnewstoday.com/articles/165756.php


Abdominal Aortic Aneurysm Repair Outcomes For Seniors Reviewed <http://www.medicalnewstoday.com/articles/165636.php>

A new study published in the Society for Vascular Surgery's October 2009 issue of the Journal of Vascular Surgery reports that the elderly have better operative outcomes when endovascular repair, rather than open surgery, is used to treat an abdominal aortic aneurysm <http://www.medicalnewstoday.com/articles/156993.php> (AAA). Researchers from the University of Wisconsin in Madison and University of Chicago examined data from the Nationwide Inpatient Sample to focus on patients between the ages of 50 and 85 and older who had had endovascular repair (EVAR) or open repair (OAR) to treat AAAs. They found that those between 50 to 64 years of age had an in-hospital operative mortality of 1.2 percent for OAR and 0.3 percent for EVAR.

http://www.medicalnewstoday.com/articles/165636.php


Source - MIT's Technology Review:

A Genetic Fountain of Youth <
http://www.technologyreview.com/biomedicine/23560/>
http://www.technologyreview.com/biomedicine/23560/


Analyzing Cancer Cells to Choose Treatments <http://www.technologyreview.com/biomedicine/23551/>
http://www.technologyreview.com/biomedicine/23560/

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