Tuesday, September 29, 2009

GBP Health / Biotech News 09-29-2009

Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ . Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.


Source - EurekAlert – Biology:


Public Release: 29-Sep-2009
Journal of Immunology
LSUHSC researcher identifies new target to prevent fatal flu lung complication
Research led by Dr. Jay Kolls, Professor and Chairman of Genetics at LSU Health Sciences Center New Orleans, has identified a therapeutic target for acute lung injury resulting in acute respiratory distress syndrome, a highly fatal complication of influenza infection.
National Institutes of Health
Contact: Leslie Capo
lcapo@lsuhsc.edu
504-568-4806
Louisiana State University Health Sciences Center

Public Release: 29-Sep-2009
New England Journal of Medicine
New blood-thinning drug safer than rat poison
A new drug has been declared to be safer but as effective as the standard anti-coagulant drug warfarin for treating patients with abnormal heart rhythms.
Contact: Steve Pogonowski
press@f1000.com
Faculty of 1000: Biology and Medicine

Public Release: 29-Sep-2009
Nanotechnology and synthetic biology: What does the American public think?
Nanotechnology and synthetic biology continue to develop as two of the most exciting areas of scientific discovery, but research has shown that the public is almost completely unaware of the science and its applications. A groundbreaking poll of 1,001 American adults conducted by Peter D. Hart Research Associates and the Project on Emerging Nanotechnologies found that 90 percent of Americans think the public should be better informed about the development of cutting-edge technologies.
Contact: Danielle Altman
danielle.altman@wilsoncenter.org
202-247-7387
Project on Emerging Nanotechnologies

Public Release: 28-Sep-2009
Journal of Experimental Medicine
UCLA study identifies 2 chemicals that could lead to new drugs for genetic disorders
UCLA scientists have identified two chemicals that convince cells to ignore premature signals to stop producing important proteins. The findings could lead to new medications for genetic diseases, such as cancer and muscular dystrophy, that are sparked by missing proteins.
Ataxia-Telangiectasia Medical Research Foundation, National Institutes of Health, Ataxia-Telangiectasia Ease Foundation
Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles

Public Release: 28-Sep-2009
American Journal of Pathology
Diabetes weakens your bones
Current research suggests that the inflammatory molecule TNF-alpha may contribute to delayed bone fracture healing in diabetics. The related report by Alblowi et al., "High Levels of TNF-alpha Contribute to Accelerated Loss of Cartilage in Diabetic Fracture Healing" appears in the October 2009 issue of the American Journal of Pathology.
Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology

Public Release: 28-Sep-2009
Journal of Experimental Medicine
UCLA study identifies 2 chemicals that could lead to new drugs for genetic disorders
UCLA scientists have identified two chemicals that convince cells to ignore premature signals to stop producing important proteins. The findings could lead to new medications for genetic diseases, such as cancer and muscular dystrophy, that are sparked by missing proteins.
Ataxia-Telangiectasia Medical Research Foundation, National Institutes of Health, Ataxia-Telangiectasia Ease Foundation
Contact: Elaine Schmidt
eschmidt@mednet.ucla.edu
310-794-2272
University of California - Los Angeles



Public Release: 27-Sep-2009
Nature Nanotechnology
U of T researchers create microchip that can detect type and severity of cancer
U of T researchers have used nanomaterials to develop a microchip sensitive enough to quickly determine the type and severity of a patient's cancer so that the disease can be detected earlier for more effective treatment.

Contact: April Kemick
april.kemick@utoronto.ca
416-978-0100
University of Toronto




Source - Science Daily:

Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.

How HIV Cripples Immune Cells
September 28, 2009
— In order to be able to ward off disease pathogens, immune cells must be mobile and be able to establish contact with each other. Scientists have discovered a mechanism in an animal model revealing ...
http://www.sciencedaily.com/releases/2009/09/090916103426.htm

Insulin Boost Restores Muscle Growth In Elderly
September 27, 2009
— Researchers have demonstrated that by increasing insulin levels above the normal range in elderly test subjects, they can restore the impaired muscle-building process responsible for age-related ...
http://www.sciencedaily.com/releases/2009/09/090925115457.htm

Revolutionary Drug Could Be New Hope For Adrenal Cancer Patients
September 28, 2009
— Medical researchers are starting a clinical trial for a drug designed to combat adrenocortical carcinoma (ACC), a rare but deadly cancer that attacks the adrenal glands. They hope the new compound, ...
http://www.sciencedaily.com/releases/2009/09/090922123925.htm

Certain Cancers More Common Among HIV Patients Than Non-HIV Patients
September 28, 2009
— Researchers have found that non-AIDS-defining malignancies such as anal and lung cancer have become more prevalent among HIV-infected patients than non-HIV patients since the introduction of ...
http://www.sciencedaily.com/releases/2009/09/090925101957.htm

Carbon Nanostructure Research May Lead To Revolutionary New Devices
September 28, 2009
— Research into carbon nanostructures may some day be used in electronic, thermal, mechanical and sensing devices for the Air ...
http://www.sciencedaily.com/releases/2009/09/090925092702.htm

Safe, Effective, Minimally Invasive Mitral Valve Repair, Suggested By Study
September 28, 2009
— Minimally invasive, patient-friendly surgical techniques are widespread, but there is little data to prompt the routine use of these techniques in mitral valve surgery, especially in cases where the ...
http://www.sciencedaily.com/releases/2009/09/090928141955.htm

Scientist Builds Imager That Identifies, Locates Individual Cancer Cells
September 28, 2009
— A biomedical engineer has spent the last four years building a better imager for preclincal studies. He can now disassemble a specimen and reassemble it into a three-dimensional digital model that ...
http://www.sciencedaily.com/releases/2009/09/090928131026.htm

Vaccine Expert Advises: Immunization Should Be Given As Early In Life As Possible
September 27, 2009
— Parents should not be worried that early vaccination would overwhelm their babies, a vaccine expert says. Recent data show that the immune system of newborns is able to respond to a world full of ...
http://www.sciencedaily.com/releases/2009/09/090914111532.htm



Source - Health Day:

Health Highlights: Sept. 29, 2009
  • EPA Warns About PCBs in School Window/Door Caulking
  • Senate Committee Discusses Dietary Supplements Regulation
  • Food Workers Heaviest Smokers: Study
  • Hundreds More Nursing Homes Candidates for Inspection: Report
  • Switch to Digital Patient Records Driven by Big Hospitals
Mini-Stroke Found to Precede 1 in 8 Strokes
Expert urges reliance on other predictive tools, but not all agree

Clot-Busting Therapy Under Review
Cardiologists looking at new generation of drugs as Plavix trial shows double dosage best for angioplasty
Clinical Trials Update: Sept. 29, 2009
  • Alzheimer's Disease
  • Atrial Fibrillation
  • Bipolar Depression
Clinical Trials Update: Sept. 28, 2009
  • Epilepsy
  • Gout Attacks
  • Migraine
Clinical Trials Update: Sept. 25, 2009
  • Atrial Fibrillation
  • Chronic Pain
  • Flu Vaccine
Clinical Trials Update: Sept. 24, 2009
  • Pain Medication
  • Endometriosis
  • Epilepsy


Source - Yahoo Biotech News:


Nabi Biopharmaceuticals Receives Grant Supporting Further NicVAX Development - GlobeNewswire - 2 hours, 49 minutes ago
ROCKVILLE, Md. -- Nabi Biopharmaceuticals and the U.S. National Institute on Drug Abuse , part of the National Institutes of Health, announced today that NIDA has agreed to extend its support for the continued development of NicVAX, Nabi's proprietary vaccine to treat nicotine addiction and prevent smoking relapse.

UPDATE -- Japanese National Institute of Health to Present New Data On Hemispherx's Vaccine Enhancer - GlobeNewswire - Mon 10:30 am ET
PHILADELPHIA -- Hemispherx Biopharma, Inc. , today announced data of Dr. Hasegawa, Director, the Japanese National Institute of Infectious Diseases was to be presented on one of Hemispherx's lead compounds, Ampligen at the 13th Conference of the Japanese Society of Vaccinology, Sapporo, Japan on September 27, 2009


Source - Google Health News:



The Swine Flu... Pandemic Or Panic?
NewsBlaze
H5N1 (Bird) flu is an influenza A virus subtype that is highly contagious among birds. Rare human infections with the H5N1 (Bird) flu virus have occurred. ...

Cincinnati Hospital May Have Cure For Sickle-Cell Disease
WLWT
CINCINNATI -- After a decade of research, Cincinnati Children's Hospital Medical Center researchers hope they've discovered a way to use gene therapy to ...

J&J buys stake in flu-vaccine developer Crucell
MarketWatch
J&J and Crucell are hoping to develop the product to combat several strains of flu, including the H1N1 and H5N1 strains. H1N1 includes those strains that ...

Gene therapy may now help treat Alzheimer
HealthJockey.com
For a national gene therapy trial, researchers from the Memory Disorders Program at Georgetown University Medical Center are busy enlisting volunteers. ...


Source - Medical News Today:



ALS Stem Cell Trial Gets FDA Go Ahead
The US Food and Drug Administration (FDA) said the first clinical trial to test a new stem cell treatment for the fatal neurodegenerative disease ALS (amyotrophic lateral sclerosis ) this month (ALS) can go ahead. The federal agency gave the green light earlier this month, allowing principal investigator and neurologist Dr Eva Feldman, the DeJong Professor of Neurology at the University of Michigan (U-M) Medical School to start Phase 1 testing of the safety and efficacy of an investigational new drug (IND) from Neuralstem, a company based in Rockville, Maryland.
http://www.medicalnewstoday.com/articles/165528.php

Cancer Research Takes Turn, Offers Potential Treatment For Macular Degeneration
Indiana University School of Medicine research and a federal small business grant have set an Indianapolis startup company on a path to develop potential new treatments for age-related macular degeneration . The National Institutes of Health has awarded a $225,000 Small Business Technology Transfer (STTR) grant to ApeX Therapeutics and its co-founder Mark R. Kelley, Ph.D., Betty and Earl Herr Professor in Pediatric Oncology Research and professor of biochemistry and molecular biology and of pharmacology and toxicology at the IU School of Medicine.
http://www.medicalnewstoday.com/articles/165448.php

Like Drugs, Surgical Innovations Must Be Evaluated Through Trials
This week The Lancet publishes a landmark series on the current state of surgical research and its problems. The series is part of The Lancet Surgery Special Issue. There is serious concern that some surgeons have failed to live up to expectations about the standards and quality of their research and practice. The Balliol Collaboration proposes a solution. Evaluating the achievements of surgical interventions is as essential as measuring the effectiveness of drugs. Up until now, surgical innovation has been weakly measured and regulated. In order to tackle the various problems in the field of surgery, the Balliol colloquia gathered surgeons and research experts from around the world. They met at the Balliol College, in Oxford, to explore how the quality of research in surgery could be improved.
http://www.medicalnewstoday.com/articles/165357.php



Source - MIT's Technology Review:


A Brighter Future for Retinal Implants
http://www.technologyreview.com/biomedicine/23539/

A Turning Point for Personal Genomes
http://www.technologyreview.com/biomedicine/23522/

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