Thursday, September 10, 2009

GBP Health / Biotech News 09-09-2009


Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ . Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.


Source - EurekAlert – Biology:

Public Release: 9-Sep-2009
BMC Medical Genetics
Michigan Tech scientists identify genes linked to Lou Gehrig's disease
Their discovery could provide scientists with valuable clues as they search for a cure. It can't come any too soon. Lead researcher Shuanglin Zhang started showing symptoms of the disease himself four years ago.
National Institutes of Health
Contact: Marcia Goodrich
mlgoodri@mtu.edu
906-487-2343
Michigan Technological University

Public Release: 9-Sep-2009
Nano Letters
Toward a nanomedicine for brain cancer
In an advance toward better treatments for the most serious form of brain cancer, scientists in Illinois are reporting development of the first nanoparticles that seek out and destroy brain cancer cells without damaging nearby healthy cells. The study is scheduled for the Sept. 9 issue of ACS' Nano Letters, a monthly journal.
Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society

Public Release: 9-Sep-2009
Journal of Natural Products
'Dung of the devil' plant roots point to new swine flu drugs
Scientists in China have discovered that roots of a plant used a century ago during the great Spanish influenza pandemic contains substances with powerful effects in laboratory experiments in killing the H1N1 swine flu virus that now threatens the world. Their report is scheduled for the Sept. 25 issue of ACS' Journal of Natural Products, a monthly publication.
Contact: Michael Woods
m_woods@acs.org
202-872-6293
American Chemical Society

Public Release: 9-Sep-2009
Nature
New type of adult stem cells found in the prostate may be involved in prostate cancer development
A new type of stem cell discovered in the prostate of adult mice can be a source of prostate cancer, according to a new study by researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center and NewYork-Presbyterian Hospital.
Contact: Elizabeth Streich
eas2125@columbia.edu
212-305-6535
Columbia University Medical Center

Public Release: 9-Sep-2009
Surgeons General, STOP Obesity Alliance announce America has reached tipping point on obesity
The two most recent Surgeons General of the United States, David Satcher, M.D., Ph.D., FAAFP, FACPM, FACP and Richard H. Carmona, M.D., M.P.H., FACS, today led the Strategies to Overcome and Prevent (STOP) Obesity Alliance in urging policymakers to take direct action in health reform to address obesity and the chronic diseases associated with it.
sanofi-aventis, Amylin Pharmaceuticals
Contact: Tom Murphy
tmurphy@ccapr.com
202-368-8571
Chandler Chicco Agency

Public Release: 7-Sep-2009
Measuring the next successful antennas for in-body health monitoring devices
Antennas for the latest implanted medical devices are being developed by Queen Mary University of London and tested through a unique piece of kit at the UK's National Physical Laboratory.
Contact: Joe Meaney
joe@proofcommunication.com
44-845-680-1864
National Physical Laboratory

Public Release: 6-Sep-2009
Society for General Microbiology Autumn 2009 Meeting
Making bacteria make useful proteins
By adapting a single protein on the surface of the bacterium Caulobacter crescentus, researchers at the University of British Columbia have turned it into a protein production factory, making useful proteins that can act as vaccines and drugs. Dr. John Smit presented the findings at the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh.
Contact: Dianne Stilwell
diannestilwell@me.com
44-795-720-0214
Society for General Microbiology


Source - Science Daily:

Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.

Scientists Identify Genes Linked To Lou Gehrig's Disease
September 9, 2009
— Researchers have linked three genes to the most common type of amyotrophic lateral sclerosis (ALS), generally known as Lou Gehrig’s ...
http://www.sciencedaily.com/releases/2009/09/090909122110.htm

Plants On Steroids: Key Missing Link Discovered Could Improve Understanding of Major Human Diseases
September 9, 2009
— Researchers have discovered a key missing link in the so-called signaling pathway for plant steroid hormones. This discovery marks the first such pathway in plants for which all the steps have been ...
http://www.sciencedaily.com/releases/2009/09/090908151338.htm

Malignant Signature May Help Identify Patients Likely To Respond To Therapy
September 9, 2009
— A molecular signature that helps account for the aggressive behavior of a variety of cancers such as pancreatic, breast and melanoma may also predict the likelihood of successful treatment with a ...
http://www.sciencedaily.com/releases/2009/09/090906161055.htm

Gene Predicts Post-surgical Survival From Brain Metastasis Of Breast Cancer Patients
September 9, 2009
— Researchers have identified a gene that may play a role in breast cancer metastasis to the ...
http://www.sciencedaily.com/releases/2009/09/090901132804.htm

Could Salmonella Bacteria Kill Tumors?
September 8, 2009
— Salmonella is regarded as a bad guy. Hardly a summer passes without reports of severe salmonella infections via raw egg dishes or chicken. But salmonella may not only harm us -- in the future, it may …
http://www.sciencedaily.com/releases/2009/09/090908104001.htm

Infections May Lead To Faster Memory Loss In Alzheimer's Disease
September 8, 2009
— Getting a cold, stomach bug or other infection may lead to increased memory loss in people with Alzheimer's disease, according to new ...
http://www.sciencedaily.com/releases/2009/09/090907162306.htm

First Evidence Of Virus In Malignant Prostate Cells: XMRV Retrovirus Linked To More Aggressive Tumors
September 8, 2009
— In a finding with potentially major implications for identifying a viral cause of prostate cancer, researchers have reported that a type of virus known to cause leukemia and sarcomas in animals has ...
http://www.sciencedaily.com/releases/2009/09/090907162310.htm

Lung Cancer Oncogene Holds Key To Turning Off Cancer Stem Cells
September 8, 2009
— Scientists have found that the lung cancer oncogene PKCiota is necessary for the proliferation of lung cancer stem cells. These stem cells are rare and powerful master cells that manufacture the ...
http://www.sciencedaily.com/releases/2009/09/090908132233.htm

Narrow-band Imaging Increases Specificity Of Early Lung Cancer Detection
September 7, 2009
— Researchers have found that narrow-band imaging bronchoscopy increases the specificity of bronchoscopic early lung cancer detection and can serve as an alternative detection ...
http://www.sciencedaily.com/releases/2009/09/090902133641.htm

Diabetes Advance: Researchers Find Gene That Causes Resistance To Insulin
September 7, 2009
— A breakthrough by an international team of researchers in Canada, France, the UK and Denmark has uncovered a new gene that could lead to better treatment of type 2 diabetes, as well as a better ...
http://www.sciencedaily.com/releases/2009/09/090906161104.htm

Cancer Drug May Improve Memory In Alzheimer's Patients
September 6, 2009
— A drug now used to treat cancer may also be able to restore memory deficits in patients with Alzheimer's disease, according to a new ...
http://www.sciencedaily.com/releases/2009/09/090907013816.htm

Two New Antibodies Found To Cripple HIV: 'Achilles' Heel On Virus For AIDS Vaccine Researchers To Exploit
September 5, 2009
— Researchers have discovered two powerful new antibodies to HIV that reveal what may be an Achilles heel on the virus. Researchers will now try to exploit the newfound vulnerability on the virus to ...
http://www.sciencedaily.com/releases/2009/09/090903163730.htm


Source - Health Day:

Health Highlights: Sept. 9, 2009
  • Baby Boomers' Hospital Care Costs Mounting: Report
  • Poor Trial Results a Setback for First Stem Cell Drug
  • HHS' Sebelius Counsels Kids With Asthma on Swine Flu
Metabolic Syndrome May Raise Risk of Peripheral Artery Disease
Women much more likely to develop PAD if they had constellation of other symptoms, researchers found
Clinical Trials Update: Sept. 9, 2009
  • Healthy Volunteers (Ages 18-40)
  • Osteoporosis
  • Gout
Scientists Spot Clue to Cancer's Aggressiveness
They hope molecular signature shows when disease will respond to cancer drug

Clinical Trials Update: Sept. 8, 2009
  • Nocturia
  • Rheumatoid Arthritis (RA)
  • Bipolar Disorder


Source - Yahoo Biotech News:

Targeted Genetics sells assets to Genzyme - AP - 2 hours, 5 minutes ago
Biotechnology company Targeted Genetics Corp. said Wednesday it is selling a series of assets to Genzyme Corp. for $7 million in cash.

Sinovac Obtains Lot Release Certificate for Its First Batch of H1N1 Vaccine - PR Newswire - Tue 9:00 am ET
Sinovac Biotech Ltd. , a leading provider of vaccines in China, today announced that the first lot of PANFLU.1, its H1N1 vaccine, has passed the lot release process of China's National Institute for the Control of Pharmaceutical and Biological Products and obtained the Certificate for the Release of Biological Products, which means the released vaccines are ready for delivery.


Source - Google Health News:


Flu pandemic giving tiny companies big stage
Reuters
But while the vaccine rush has given companies new opportunities for grants and some the chance to test their technologies on people, few will actually have ...

Vaxart Awarded NIH Grant to Support Development of Orally ...
PR Newswire (press release)
... Infectious Disease (National Institutes of Health) to support development of its first product, an orally-delivered vaccine for H5N1 Avian influenza. ...

Boosting our best shot
Nature.com (subscription)
Pulendran has applied this principle most recently to create experimental vaccines against the H1N1 'swine flu' virus and the H5N1 'bird flu' virus. ...

Gene therapy could cut new Alzheimer's cases by a fifth
Belfast Telegraph
Gene scientists have taken a “leap forward” in Alzheimer's research with the potential to cut rates of the disease by a fifth, it has been revealed. ...


Source - Medical News Today:

New Chapter In Drug Development Opened By Cell Discovery
British scientists have uncovered new details about how the cells in our bodies communicate with each other and their environment: findings that are of fundamental importance to human biology. Cells 'talk' to each other through a complex process called 'signalling'. When these signals go wrong, it can lead to all kinds of diseases, including cancer , diabetes and arthritis , to name but a few.
http://www.medicalnewstoday.com/articles/163363.php

Pancreatic Tumor Rejection Can Be Induced By Autoimmune Response
Immune responses are capable of killing tumors before they can be directed toward normal body tissue, according to new scientific findings published in Cancer Research, a journal of the American Association for Cancer Research. "There are extremely precise mechanistic methods augmenting the ability of the immune system to distinguish between normal tissues and tumors," said lead researcher Richard G. Vile, Ph.D. "Understanding the multiple checks and safeguards against autoimmunity should allow us to understand more closely how to generate antitumor immunity."
http://www.medicalnewstoday.com/articles/163358.php

'Second Hit' Pushes Noninvasive Breast Cancer Towards Deadly Metastasis
A new study identifies a molecule that acts cooperatively with a well known oncoprotein to drive progression of noninvasive breast cancer to metastatic, life-threatening disease. The research findings, published by Cell Press in the September issue of the journal Cancer Cell, could have a significant impact on therapeutic decisions by facilitating identification of high risk patients. Elevated ErbB2, a well known invasion and metastasis promoting protein, is found in about one quarter of invasive breast cancers (IBC) and is associated with poor patient survival. However, ErbB2 is also overexpressed in more than half of noninvasive ductal carcinomas in situ (DCIS). DCIS, which is characterized by proliferation of malignant cells within mammary ducts with no invasion into surrounding tissues, is a precursor of IBC.
http://www.medicalnewstoday.com/articles/163314.php

Dementia Mysteries Unveiled By Largest Ever Alzheimer's Gene Study
The results, from the largest ever Alzheimer's genome-wide association study (GWAS) involving 16,000 individuals, are published in Nature Genetics. They are the first new genes found to be associated with the common form of Alzheimer's disease since 1993. The Alzheimer's Research Trust spoke of "a leap forward for dementia research", the MRC's Sir Leszek Borysiewicz praised "a huge step towards achieving an earlier diagnosis of Alzheimer's", and the Welsh First Minister Rhodri Morgan hailed the Cardiff-led study as "a real feather in the cap of Welsh science".
http://www.medicalnewstoday.com/articles/163227.php


Source - MIT's Technology Review:

Clues to Blast-Related Brain Injury
http://www.technologyreview.com/biomedicine/23368/

New DNA Markers for Alzheimer's
http://www.technologyreview.com/biomedicine/23379/

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