Source - EurekAlert – Biology:
Public Release: 23-Jul-2009
The disease markers that will aid arthritis research
A combination of biochemical and MRI markers will allow improved measurement of osteoarthritis progression. The biomarkers, described in BioMed Central's open-access journal Arthritis Research and Therapy, will be useful for the design and interpretation of trials of new disease modifying drugs.
Contact: Graeme Baldwin
graeme.baldwin@biomedcentral.com
44-203-192-2165
BioMed Central
Public Release: 23-Jul-2009
Resistance to antibiotics: When 1+1 is not 2
The evolution of multiple antibiotic resistances is a global and difficult problem to eradicate. Isabel Gordo, a group leader at the Instituto Gulbenkian de Ciência, Portugal, reports in the paper published in the latest issue of PLoS Genetics, that the deleterious effect associated with the acquisition of resistance by a bacteria can be suppressed by the acquisition of a new resistance to another antibiotic.
Contact: Silvia Castro
sacastro@igc.gulbenkian.pt
351-214-464-537
Instituto Gulbenkian de Ciencia
Public Release: 23-Jul-2009
Injection reverses heart-attack damage
Injured heart tissue normally can't regrow, but researchers at Children's Hospital Boston now offer a groundwork for regenerating heart tissue after a heart attack, in patients with heart failure, or in children with congenital heart defects. In this week's Cell, they show that a growth factor involved in the development of the heart and nervous system can spur heart-muscle growth and recovery of cardiac function when injected systemically into animals after a heart attack.
Contact: Rob Graham
rob.graham@childrens.harvard.edu
617-919-3110
Children's Hospital Boston
Public Release: 23-Jul-2009
Stripping leukemia-initiating cells of their 'invisibility cloak'
Two new studies reveal a way to increase the body's appetite for gobbling up the cancer stem cells responsible for acute myeloid leukemia (AML), a form of cancer with a particularly poor survival rate. The key is targeting a protein on the surface of those cells that sends a "don't eat me" signal to the macrophage immune cells that serve as a first line of defense, according to the reports in the July 24 issue of the journal Cell, a Cell Press publication.
Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Public Release: 23-Jul-2009
Stem cells not the only way to fix a broken heart
Researchers appear to have a new way to fix a broken heart. They have devised a method to coax heart muscle cells into reentering the cell cycle, allowing the differentiated adult cells to divide and regenerate healthy heart tissue after a heart attack, according to studies in mice and rats reported in the July 24 issue of the journal Cell, a Cell Press publication.
Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press
Public Release: 23-Jul-2009
OMT announces a breakthrough in the development of a novel human antibody platform
OMT, in collaboration with Sangamo, Sigma-Aldrich, the Medical College of Wisconsin and INSERM, created the first targeted knockout rats with permanent heritable genetic mutations, as published in the July 24, 2009, edition of Science.
Contact: Dr. Roland Buelow
rbuelow@omtinc.net
650-224-6835
Open Monoclonal Technology, Inc.
Public Release: 23-Jul-2009
Newly discovered gene fusion may lead to improved prostate cancer diagnosis
Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new gene fusion that is highly expressed in a subset of prostate cancers.
Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560
New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College
Public Release: 22-Jul-2009
ORNL advances therapy for Parkinson's, other diseases
By miniaturizing a device that monitors the delivery of healthy cells, researchers at US Department of Energy's Oak Ridge National Laboratory are developing a powerful instrument for physicians to use in treating patients with Parkinson's syndrome, brain tumors and other diseases.
Contact: Ron Walli
wallira@ornl.gov
865-576-0226
DOE/Oak Ridge National Laboratory
Public Release: 21-Jul-2009
Twinkling nanostars cast new light into biomedical imaging
Researchers have created magnetically responsive gold nanostars that may offer a new approach to biomedical imaging. The nanostars gyrate when exposed to a rotating magnetic field, and can scatter light to produce a pulsating or "twinkling" effect. This twinkling allows them to stand out more clearly from noisy backgrounds like those found in biological tissue.
Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source - Science Daily:
Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.
Copper Can Help In The Battle Against Influenza A H1N1, Says Scientist
July 24, 2009 — A leading microbiologist says his research has found copper is effective in inhibiting the influenza A H1N1 ...
http://www.sciencedaily.com/releases/2009/07/090723201456.htm
Breakthrough In Transgenic Animal Production Enables Development Of New Human Disease Models
July 24, 2009 — Scientists have announced the creation of the first genetically modified mammals developed using zinc finger nuclease ...
http://www.sciencedaily.com/releases/2009/07/090723141751.htm
Halting A Pandemic: NIH Mounts Search For A H1N1 Vaccine
July 24, 2009 — Bracing for an outbreak of 2009 H1N1 (swine-origin) flu that an infectious diseases expert estimates could sicken one in five people this fall, scientists are launching a series of clinical trials ...
http://www.sciencedaily.com/releases/2009/07/090722083720.htm
Therapy For Parkinson's, Other Diseases Advanced With Miniaturization Of Device
July 23, 2009 — By miniaturizing a device that monitors the delivery of healthy cells, researchers are developing a powerful instrument for physicians to use in treating patients with Parkinson's syndrome, brain ...
http://www.sciencedaily.com/releases/2009/07/090722165503.htm
Potential New Drug Target For Diabetes And Alzheimer's Disease
July 23, 2009 — A cellular protein that may prevent nerve cells from dying also helps to improve insulin action and lower blood glucose levels, according to a new ...
http://www.sciencedaily.com/releases/2009/07/090721214620.htm
Bcl6 Gene Sculpts Helper T Cell To Boost Antibody Production
July 23, 2009 — Expression of a single gene programs an immune system helper T cell that fuels rapid growth and diversification of antibodies in a cellular structure implicated in autoimmune diseases and development ...
http://www.sciencedaily.com/releases/2009/07/090723150830.htm
Common Cold Virus Efficiently Delivers Corrected Gene To Cystic Fibrosis Cells
July 22, 2009 — Scientists have worked for 20 years to perfect gene therapy for the treatment of cystic fibrosis, which causes the body to produce dehydrated, thicker-than-normal mucus that clogs the lungs and leads ...
http://www.sciencedaily.com/releases/2009/07/090720202603.htm
Insights Into Failed HIV-1 Vaccine Trial
July 22, 2009 — The leading explanation for why the Merck HIV-1 vaccine candidate was ineffective is ruled out in new ...
http://www.sciencedaily.com/releases/2009/07/090720190810.htm
Promising New Treatment For Alzheimer’s Disease
July 22, 2009 — A promising approach has been developed to help treat Alzheimer’s disease in a significant proportion of the population that suffers from a particularly rapid development of this ...
http://www.sciencedaily.com/releases/2009/07/090720083210.htm
Tumor 'Stem-like Cells' Exist In Benign Tumors
July 22, 2009 — Cancer stem-like cells have been implicated in the genesis of a variety of malignant cancers. Research scientists have now isolated stem-like cells in benign (pituitary) tumors and used these ...
http://www.sciencedaily.com/releases/2009/07/090723113707.htm
Clinical Trials To Test 2009 H1N1 Influenza Vaccine Candidates Set
July 22, 2009 — Scientists in a network of medical research institutions across the United States are set to begin a series of clinical trials to gather critical data about influenza vaccines, including two ...
http://www.sciencedaily.com/releases/2009/07/090722142836.htm
Source - Health Day:
Health Highlights: July 24, 2009
- Senate Puts Off Vote on Health-Care Legislation
- Poll Still Finds Public Support for Health-Care Reform
- Study Looks at Implanted Pig Cells to Treat Type 1 Diabetes
- Swine Flu Fears Prompt Arab States to Limit Pilgrimage
Study finds strong association in postmenopausal women
Stem Cells Used for 'Biological Pacemaker'
In experiments with mice, researchers corrected electrical problems of the heart
Clinical Trials Update: July 23, 2009
- Osteoarthritis of the Hip or Knee
- Heart Disease
- Alzheimer's Disease
- Postmenopausal Osteoporosis Prevention
- Healthy Volunteers (Ages 18+)
- Depression
Source - Yahoo Biotech News:
Seattle Genetics Initiates Brentuximab Vedotin (SGN-35) Retreatment Clinical Trial
BOTHELL, Wash.----Seattle Genetics, Inc. today announced that it has initiated a phase II clinical trial of brentuximab vedotin , an antibody-drug conjugate , for the retreatment of patients with Hodgkin lymphoma and systemic anaplastic large cell lymphoma .
Merck and Schering offer to settle merger lawsuit
Merck & Co. and Schering-Plough Corp. said Friday they are offering to disclose new information about their planned tie-up to settle a class action lawsuit by shareholders
Source - Google Health News:
"Single-Shot" Vaccines Could Protect Against H5N1 Influenza Virus
RedOrbit - Dallas,TX,USA
The use of adjuvants (substances to improve the immune response) in vaccine development may lower the antigen dose required and ultimately ease the demand ...
Swine flu: intensive care beds will be swamped experts warn
Telegraph.co.uk - United Kingdom
The UK Government has ordered up to 132 million doses of the vaccine from both GSK and Baxter. Around 60 million doses – enough for half the population at ...
Effect of Different Vaccines in H5N1 Pandemic Compared Vaccine ...
Modern Medicine - Woodcliff Lake,NJ,USA
"Taken together, these findings suggest that, at present, the H5N1 vaccine formulation that includes a low antigen dose and a non-aluminum adjuvant (which, ...
Common cold virus may help treat cystic fibrosis
SINDH TODAY - Sindh,Pakistan
Scientists have worked for 20 years to perfect gene therapy for the treatment of cystic fibrosis, which causes the body to produce dehydrated, ...
Source - Medical News Today:
Key Event In Prostate Cancer Progression Discovered By Scientists
A study led by researchers at the Ohio State University Comprehensive Cancer Center and Dana-Farber Cancer Institute reveals how late-stage, hormone-independent prostate tumors gain the ability to grow without need of hormones. The onset of hormone-independent growth marks an advanced and currently incurable stage of prostate cancer.
http://www.medicalnewstoday.com/articles/158757.php
Deep Vein Thrombosis: The Risk During A Flight Is Often Overestimated
The risk of developing deep vein thrombosis during a long flight is often overestimated. According to the German Institute for Quality and Efficiency in Health Care (IQWiG), this condition is very unlikely in healthy travellers. When people wear a cast or splint after a sports accident, on the other hand, many are not aware that they have an increased risk of deep vein thrombosis in their leg and pelvic area. This is emphasised in information published on IQWiG's website Informed Health Online.
Blood clots can travel to lungs, leading to pulmonary embolism
http://www.medicalnewstoday.com/articles/158667.php
Alzheimer's-Causing Amyloid And Bacteria Trigger Same Immune Response In The Brain
In a new study published today in the July issue of the journal Cell Host & Microbe, UC Davis researchers report that both amyloid plaques found in the brains of Alzheimer's patients and structures made by some gut bacteria likely elicit the same response by human immune cells. "Alzheimer's disease may be a case of mistaken identity," said Andreas Bäumler, a professor of microbiology and medical immunology. Bäumler and his colleagues showed that the immune systems of mice injected with E. coli and salmonella are triggered by curli fibrils, fiber-like structures consisting of curli proteins that allow bacteria to stick to host tissue and to each other and form colonies.
http://www.medicalnewstoday.com/articles/158628.php
Enhanced Digital Breast Imaging From US Navy-Funded Technology
A breakthrough technology adapted for breast cancer detection based in part on research originally sponsored by the Office of Naval Research (ONR) is set to air July 23 during a CNN International news segment on Vital Signs, a program hosted by Dr. Sanjay Gupta. The technology, referred to by the U.S. Navy as enhanced digital imaging, developed out of the Navy's need to improve capabilities to detect, localize and classify underwater mines. It later served as the point of departure for research conducted by the Naval Undersea Warfare Center, Division Newport (NUWC), part of the Naval Sea Systems Command (NAVSEA), designed to enhance the discrimination of data in complex underwater environments. Researchers at NUWC later patented the enhanced digital imaging process.
http://www.medicalnewstoday.com/articles/158604.php
Stem Cell Projects Pave The Way For New Therapies
The Medical Research Council has announced funding for seven awards totalling £4.7 million under its translational stem cell research scheme. This includes nearly £3 million for four early stage clinical trials involving adult stem cells
http://www.medicalnewstoday.com/articles/158412.php
Neural Stem Cells Offer Potential Treatment For Alzheimer's Disease
UC Irvine scientists have shown for the first time that neural stem cells
http://www.medicalnewstoday.com/articles/158268.php
Source - MIT's Technology Review:
The Business of Personal Genomes
http://www.technologyreview.com/biomedicine/23058/
A Cell-Phone Microscope for Disease Detection
http://www.technologyreview.com/biomedicine/23059/
Protein Treatment Repairs Heart Damage
http://www.technologyreview.com/biomedicine/23060/
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