Friday, July 9, 2010

GBP Health / Biotech News Digest 07-08-2010

GBP Health / Biotech News 07-08-2010:

Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ . Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.


EurekAlert - Biology:

Public Release: 8-Jul-2010
Molecular Cell
DNA discovery opens new door to develop tools, therapies for hereditary cancers
McMaster University researchers have revealed new avenues to develop assessment tools and alternative treatments for people living with hereditary colorectal cancers.
National Sciences and Engineering Research Council of Canada, German Science Foundation
Contact: Veronica McGuire
vmcguir@mcmaster.ca
90-552-591-402-2169
McMaster University

Public Release: 8-Jul-2010
American Journal of Pathology
Professor discovers way to slow the growth of malignant melanoma
New Queen's University research has shown that the growth of melanoma, one of the most deadly forms of skin cancer, can be slowed when a little known gene called microRNA 193b is added. "This is the first step in a long road towards finding a melanoma cure," says Professor Victor Tron.
Contact: Michael Onesi
Michael.Onesi@queensu.ca
613-533-6000 x77513
Queen's University

Public Release: 8-Jul-2010
Cell
Housing upgrade shrinks tumors in mice with cancer
When mice with cancer get a boost in their social life and an upgrade in living conditions, their tumors shrink, and their cancers more often go into spontaneous remission Reported in the July 9 issue of the journal Cell, a Cell Press publication, these findings offer powerful new evidence of the critical role that social connection and an individual's mental state, may play in cancer.
Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press

Public Release: 8-Jul-2010
Cell
A chemical to make brain cells grow
Scientists have identified a chemical that makes new neurons grow. The substance works specifically in a part of the brain that is integral to learning and memory.
Contact: Cathleen Genova
cgenova@cell.com
617-397-2802
Cell Press

Public Release: 8-Jul-2010
Cell
Small molecule boosts production of brain cells, protects new cells from dying
UT Southwestern Medical Center researchers have found a compound that preserves newly created brain cells and boosts learning and memory in an animal study.
National Institutes of Health, Hartwell Foundation, NARSAD, Staglin Family Fund, UT Southwestern, Morton H. Meyerson Family Tzedakah Fund, Simons Foundation, et al.
Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center

Public Release: 7-Jul-2010
Journal of Alzheimer's Disease
High blood levels of vitamin E reduces risk of Alzheimer's
High levels of several vitamin E components in the blood are associated with a decreased risk for Alzheimer's disease in advanced age, suggesting that vitamin E may help prevent cognitive deterioration in elderly people. This is the conclusion reached in a Swedish study published in the July 2010 issue of the Journal of Alzheimer's Disease.
Contact: Ulla Bredberg
pressinfo@ki.se
Karolinska Institutet

Public Release: 7-Jul-2010
Gene Therapy
Genetically reprogrammed HSV given systemically shrinks distant sarcomas
Scientists have used a genetically reprogrammed herpes virus and an anti-vascular drug to shrink spreading distant sarcomas designed to model metastatic disease in mice -- still an elusive goal when treating humans with cancer, according to a study in the July 8 Gene Therapy. The study results are even more significant because the oncolytic herpes virus was given to the mice systemically to attack tumors via the blood stream instead of being injected directly into tumors
Cincinnati Children's Division of Hematology/Oncology, teeoffagainstcancer.org, Katie Linz Foundation, Limb Preservation Foundation, American Cancer Society, National Institutes of Health
Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center

Public Release: 6-Jul-2010
Analytical Chemistry
Multicolor quantum dots aid in cancer biopsy diagnosis
The tunable fluorescent nanoparticles known as quantum dots make ideal tools for distinguishing and identifying rare cancer cells in tissue biopsies. Researchers at Emory and Georgia Tech have learned how multicolor quantum dots linked to antibodies can distinguish the Reed-Sternberg cells that are characteristic of Hodgkin's lymphoma.
NIH/National Cancer Institute
Contact: Holly Korschun
hkorsch@emory.edu
404-727-3990
Emory University



Source - Science Daily:
Please note : Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary , rather than the article title.

Pinpoint Precision: Delivering a Biochemical Payload to One Cell
July 8, 2010 — Researchers use precise electrical "tweezers" to place nanowires on predetermined spots on single cells. The technique eventually could produce new ways to deliver ...
http://www.sciencedaily.com/releases/2010/07/100707102441.htm


Turning Back the Cellular Clock: Method Developed for Tracking Adult Stem Cells as They Regress
July 8, 2010 — For the first time, scientists have succeeded in tracking the progression of reprogrammed stem cells through live imaging to learn more about how they are reprogrammed, and how the new cells evolve ...
http://www.sciencedaily.com/releases/2010/06/100629122950.htm


Revolutionary Medical Dressing Uses Nanotechnology to Fight Infection
July 8, 2010 — Researchers are using nanotechnology to develop a medical dressing which will detect and treat infection in wounds. Scientists in the UK are working together with teams across Europe and Australia to ...
http://www.sciencedaily.com/releases/2010/07/100707211621.htm


Cancer Deaths Continue to Drop
July 7, 2010 — The continued drop in overall cancer mortality rates over the last 20 years has averted more than 767,000 cancer deaths, according to a new report from the American Cancer ...
http://www.sciencedaily.com/releases/2010/07/100707112429.htm


Scientists Design New Delivery Device for Gene Therapy
July 7, 2010 — Scientists have designed a nanoparticle that appears to effectively deliver genetic material into cells with minimal toxic effects. In lab experiments, the researchers have found that this device, a ...
http://www.sciencedaily.com/releases/2010/07/100706161801.htm


Patients With Treatment-Resistant CLL Respond Positively to Stem Cell Transplants
July 7, 2010 — Allogeneic (donor-derived) stem cell transplant may be a promising option for patients with treatment-resistant chronic lymphocytic leukemia (CLL), regardless of the patient's underlying genetic ...
http://www.sciencedaily.com/releases/2010/07/100702092205.htm


Best Tests for Predicting Alzheimer's Disease Identified
July 7, 2010 — New research has identified the memory and brain scan tests that appear to predict best whether a person with cognitive problems might develop Alzheimer's ...
http://www.sciencedaily.com/releases/2010/06/100630162351.htm


Novel Protein Being Tested as Potential Target in Alzheimer's Treatment
July 7, 2010 — Scientists have discovered a previously unreported mitochondrial protein that interacts with a protein known to play a role in Alzheimer's ...
http://www.sciencedaily.com/releases/2010/07/100707221744.htm


New 3-D Imaging Techniques for Improved Lung Cancer Drug Development
July 7, 2010 — Advanced imaging technologies that promise to improve effective drug development to treat lung cancer are the focus of the current issue of Optics Express. Research outlines standardized approaches ...
http://www.sciencedaily.com/releases/2010/07/100707122038.htm


Neural Stem Cells Attack Glioblastoma Cells
July 6, 2010 — Scientists in Germany have demonstrated how the brain's own stem cells and precursor cells control the growth of glioblastomas. Of all brain tumors, glioblastomas are among the most common and most ...
http://www.sciencedaily.com/releases/2010/07/100706103410.htm


Researchers Identify Factors Behind Blood-Making Stem Cells
July 6, 2010 — Researchers have made significant progress in the understanding of blood-producing (hematopoietic) stem cells. The study identifies factors that control the production of hematopoietic stem cells and ...
http://www.sciencedaily.com/releases/2010/07/100706150620.htm


How Loss of Key Protein Promotes Aggressive Form of Leukemia
July 4, 2010 — New research illuminates in fine detail one of the genetic paths that leads to a particularly aggressive form of leukemia. A team discovered a new tumor-suppressing function of p53, distinct, for ...
http://www.sciencedaily.com/releases/2010/07/100701131449.htm



Source - Health Day:
Health Highlights: July 8, 2010
· Docs Perform 1st Face Transplant Including Eyelids, Tear Ducts
· Obesity Leads to Inactivity in Kids: Study
· New Rules May Ease Veterans' Claims for PTSD Compensation
· FDA OKs Mini Eye Telescope for Macular Degeneration
Many Docs Deliver Cancer Diagnosis Badly: Study
Devastating news relayed by phone, in public hospital locations, survey finds

Clinical Trials Update: July 8, 2010
· Benign Prostatic Hypertrophy (BPH)
· Chronic Low Back Pain
· Gout
Clinical Trials Update: July 7, 2010
· Malaria Vaccine
· Chronic Pain
· Psoriasis
Clinical Trials Update: July 6, 2010

· Flu Symptoms (Ages 55-80)
· Alzheimer's Disease (Ages 50+)
· Major Depression



Source - Yahoo Biotech News:

Merck Details Plans to Advance Integration of R&D, Manufacturing and Business Operations Worldwide - Business Wire - Thu 9:00 am ET
WHITEHOUSE STATION, N.J.----Merck & Co., Inc. , known outside the U.S. and Canada as MSD, today provided further detail on integration plans for the company's research and development, manufacturing and other business operations as part of a global restructuring program announced following the November 2009 merger of Merck and Schering-Plough.



Source - Google Health News:

Study Shows Hope for Gene Therapy
HealthNewsDigest.com
By Wall Street Journal Online (HealthNewsDigest.com) - Researchers have launched a new gene-therapy trial for children with a rare disease known as "bubble ...

Cancer Treatment Advancements
KULR-TV
The Billings Clinic Cancer Research Center is focusing on immuno and gene therapy. "The information that we've learned about cancer is doubling every few ...

Study Shows Hope for Gene Therapy
Wall Street Journal
By AMY DOCKSER MARCUS Researchers have launched a new gene-therapy trial for children with a rare disease known as "bubble boy syndrome," reflecting fresh ...

Scientists Hope to Use Gene Therapy to Treat HIV
Tech Jackal
Scientists have learned there may be a way to prevent the spread of HIV by using genetic therapy. The process has been tested on mice and will hopefully ...

UAB scientists working on gene therapy that may cure sickle cell
al.com (blog)
(Illumina) Scientists at UAB say they're edging closer to a possible cure for sickle cell disease, one that uses gene therapy to repair diseased cells and ...



Source - Medical News Today :

HIV Prevention Strategy Key To Curbing Epidemic And Cutting Long-Term Treatment Costs
Increasing highly active antiretroviral therapy (HAART) treatment for people with HIV/AIDS will provide significant cost savings over a relatively short period of time, according to a formal economic analysis led by researchers at the BC Centre for Excellence in HIV/AIDS (BC-CfE) at Providence Health Care and the University of British Columbia (UBC). The analysis of HAART coverage in British Columbia, published recently in AIDS , the official journal of the International AIDS Society (IAS), is the first comprehensive economic evaluation of the net benefit of HAART in the province. HAART lowers viral load, stopping HIV from progressing to AIDS in individuals and helping to prevent HIV transmission. The study's key finding shows that while expanding HAART use is cost-effective for individual patients, the benefits become exponentially greater when HAART's ability to prevent HIV transmission is considered.
www.medicalnewstoday.com/articles/194108.php

Are Doctors Giving Patients The Best Vaccines Or The Vaccines With The Best Price?
Yesterday, Citizens for Responsibility and Ethics in Washington (CREW) sent a letter to the Federal Trade Commission (FTC) asking for an antitrust investigation into drug companies that offer significant discounts to doctors for providing patients with only that company's vaccines. CREW sent its letter after learning that Sanofi Pasteur and Merck require physician healthcare groups purchasing their vaccines to enter into contracts prohibiting them from purchasing vaccines made by other companies. CREW Executive Director Melanie Sloan stated, "Patients presume that doctors choose vaccines based on the patient's best interests. Now we learn that's not always true. In some cases, doctors are choosing vaccines based on the discounts offered by the drug manufacturer."
www.medicalnewstoday.com/articles/194027.php

Researchers Explore Novel Protein As Potential Target In Alzheimer's Treatment
A South Dakota State University researcher and his colleagues elsewhere have discovered a previously unreported mitochondrial protein that interacts with a protein known to play a role in Alzheimer's disease . The discovery adds to what is known about the memory-inhibiting disease as researchers continue to search for ways to treat it.
www.medicalnewstoday.com/articles/193752.php




Source - MIT's Technology Review :

Multiplying DNA One Drop at a Time
http://www.technologyreview.com/biomedicine/25762/

Multistep Diagnostics on Paper
http://www.technologyreview.com/biomedicine/25760/

Targeting a Master Regulator of Disease
http://www.technologyreview.com/biomedicine/25703/

Biosensors Comfortable Enough to Wear 24-7
http://www.technologyreview.com/biomedicine/25701/


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