Wednesday, June 2, 2010

GBP Health/Biotech 06-02-2010

GBP Health / Biotech News 06-02-2010:

Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/
. Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.

EurekAlert - Biology:

Public Release: 2-Jun-2010
Journal of Agricultural and Food Chemistry
Peaches, plums induce deliciously promising death of breast cancer cells
Breast cancer cells -- even the most aggressive type -- died after treatments with peach and plum extracts in lab tests at Texas AgriLife Research recently, and scientists say the results are deliciously promising. Not only did the cancerous cells keel over, but the normal cells were not harmed in the process.
Vegetable and Fruit Improvement Center at Texas A&M University, US Department of Agriculture, California Tree Fruit Agreement

Contact: Kathleen Phillips
ka-phillips@tamu.edu
979-845-2872

Texas A&M AgriLife Communications

Public Release: 1-Jun-2010
Journal of Experimental Medicine
Making enough red blood cells
Two small molecules ensure enough red blood cells are produced, scientists at EMBL Monterotondo and EMBL-EBI found in a study published today in the Journal of Experimental Medicine.

Contact: Sonia Furtado
sonia.furtado@embl.de
European Molecular Biology Laboratory

Public Release: 1-Jun-2010
Journal of Clinical Investigation
Eliminating tumor suppressor C/EBP alpha explains cancer in aging liver
Understanding how the tumor suppressor protein C/EBP alpha is eliminated in aging livers gives important clues to the mechanism by which cancer occurs in that organ and could point the way to new therapies and prevention, said Baylor College of Medicine. A variant of C/EBP alpha called the S193-ph isoform is such a powerful tumor suppressor protein that it must be eliminated before liver cancer can occur.
National Institutes of Health

Contact: Dipali Pathak
pathak@bcm.edu
713-798-4710

Baylor College of Medicine

Public Release: 1-Jun-2010
Cancer Research
Calcium consumption may cause prostate cancer in Chinese
Among Chinese men, calcium consumption -- even at relatively low levels and from non-dairy food sources such as soy, grains and green vegetables -- may increase prostate cancer risk, according to results published in Cancer Research, a journal of the American Association for Cancer Research.

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558

American Association for Cancer Research

Public Release: 1-Jun-2010
SNM's 57th Annual Meeting
TU Delft and MI Labs merge PET and SPECT biomedical imaging techniques and increase resolution
TU Delft and Molecular Imaging Labs (MI Labs) have succeeded in combining two forms of medical imaging techniques (microPET and microSPECT) into one piece of equipment. These techniques can be performed simultaneously and give a higher resolution than traditional microSPECT and microPET. The new device is designed for use in fundamental research into the functioning of cells and organs. It can show functional details smaller than half a millimeter.

Contact: Ilona van den Brink
i.vandenbrink@tudelft.nl
31-152-784-259
Delft University of Technology

Public Release: 1-Jun-2010

Sugary band-aid may help heal post-operative tissue
A compound found in sunless tanning spray may help to heal wounds following surgery, according to new results published by plastic surgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City and biomedical engineers at Cornell University in Ithaca, N.Y., where the novel compound was developed.
National Science Foundation, Morgan Tissue Engineering Fund, Wallace H. Coulter Foundation, New York State Center for Advanced Technology

Contact: Andrew Klein
ank2017@med.cornell.edu
212-821-0560

New York- Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College

Source - Science Daily :

Please note : Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary , rather than the article title.

Immune System Helps Transplanted Stem Cells Navigate in Central Nervous System

June 2, 2010 — By discovering how adult neural stem cells navigate to injury sites in the central nervous system, researchers have helped solve a puzzle in the creation of stem cell-based treatments: How do these ...

http://www.sciencedaily.com/releases/2010/06/100601162300.htm

Synthetic Peptide May Regenerate Brain Tissue in Stroke Victims

June 2, 2010 — A synthetic version of a naturally occurring peptide promoted the creation of new blood vessels and repaired damaged nerve cells in lab animals, according to ...

http://www.sciencedaily.com/releases/2010/06/100601101410.htm

No Relaxing for Cancer Cells

June 2, 2010 — Many tumor cells would not be viable due to aberrant chromosome distribution if they had not developed a special trick. Scientists in Germany have investigated which genes are responsible for this ...

http://www.sciencedaily.com/releases/2010/06/100601101416.htm

Ablation Proved as Effective as Traditional Surgery in Treating Kidney Cancer

June 2, 2010 — A minimally invasive technique used to destroy kidney tumors with an electrically controlled heating probe showed similar effectiveness as surgical removal of tumors in curbing cancer recurrence ...

http://www.sciencedaily.com/releases/2010/06/100602121212.htm

A Prognostic and Predictive Biomarker for Nonsmall Cell Lung Cancer

June 1, 2010 — Researchers in Brazil found a protein that can be used to indicate which patients in the early stages of nonsmall cell lung cancer (NSCLC) have a good prognosis and which do not. High levels of this ...

http://www.sciencedaily.com/releases/2010/06/100601205800.htm

Targeted Immunotherapy Shows Promise for Metastatic Breast, Pancreatic Cancers

June 1, 2010 — Early trials using targeted monoclonal antibodies in combination with existing therapies show promise in treating pancreatic cancer and metastatic breast cancer, according to new ...

http://www.sciencedaily.com/releases/2010/06/100601124137.htm

Bone Marrow Plays Critical Role in Enhancing Immune Response to Viruses, Researchers Find

June 1, 2010 — Researchers for the first time have determined that bone marrow cells play a critical role in fighting respiratory viruses, making the bone marrow a potential therapeutic target, especially in people ...

http://www.sciencedaily.com/releases/2010/05/100524143423.htm

New Pathway to Cheap Insulin

June 1, 2010 — Researchers have now developed a new method to cheaply produce insulin for the treatment of ...

http://www.sciencedaily.com/releases/2010/05/100526095652.htm

Challenges for the Next Pandemic

June 1, 2010 — Six public health challenges and data needs are evident, based upon lessons learned from the 2009 influenza ...

http://www.sciencedaily.com/releases/2010/06/100601171717.htm

Only 5 Percent of Cancer Research Funds Are Spent on Metastases, Yet It Kills 90 Percent of All Cancer Patients

June 1, 2010 — On average, about 5 percent of total cancer research funding is spent on investigating metastases (the spread of cancer cells around the body) in Europe, yet metastatic disease is the direct or ...

http://www.sciencedaily.com/releases/2010/06/100601101420.htm

Comparison of Overall Survival for Non-Small Cell Lung Cancer Patients

May 31, 2010 — Patients with early stages of NSCLC are typically treated with surgery, but those with stage IIIA present more of a challenge because they are such a diverse group. However, new research shows that ...

http://www.sciencedaily.com/releases/2010/05/100528210734.htm

Source - Health Day:

Health Highlights: June 2, 2010

  • Midnight Snacks Harm Teeth: Study
  • Companies Offer Employees Money to Lose Weight
  • More States Require Phys Ed for Students: Report
  • FDA Approves New Bone Drug

Male 'Pill' Still a Ways Off
Shutting down sperm production has proved complicated, experts say

More Cancer-Causing Chemicals in U.S. Cigarettes
They contain about 3 times as much of a potent carcinogen as foreign brands, CDC finds

Clinical Trials Update: June 2, 2010

  • Osteoarthritis of Knee
  • Gout
  • Type 2 Diabetes

Source - Yahoo Biotech News:

FDA clears Amgen's bone-strengthening drug, Prolia- AP - Tue 6:56 pm ET
The Food and Drug Administration on Tuesday approved Amgen's bone strengthening drug, Prolia, for postmenopausal women at risk for fractures, a potential blockbuster market

Congress investigating J&J 'phantom recall'- AP - Tue 2:11 pm ET
Congressional Democrats are investigating an alleged "phantom recall" by Johnson & Johnson, in which the company hired a contractor to buy up defective painkillers instead of issuing an immediate recall.

Source - Google Health News:

Ending the Suspense, Celladon's Gene Therapy Helps Heart Failure Patients in ...
Xconomy
Gene therapy has never lived up to two decades of hype, but some intriguing new evidence for the technology emerged over the weekend at a medical meeting in ...

NanoViricides announces positive results for dengue target
Mass High Tech
There is currently no approved vaccine or treatment for the dengue virus infection. ... is also developing drugs against H5N1 bird flu, seasonal influenza, ...

First-in-man gene therapy for advanced heart failure promising in small study
TheHeart.Org
Berlin, Germany - In the first clinical test of a gene therapy for heart failure, administration of a gene that upregulates an enzyme involved in myocardial ...

Tweaking Genes May Fix Broken Hearts
ABC News
After six months, patients who received the highest dose of the gene therapy had less worsening of a six-minute walk test, as well as evidence of less rapid ...

Hopes for breast cancer vaccine
BBC News
American scientists say they have developed a vaccine which has prevented breast cancer from developing in mice. The researchers - whose findings are ...

Source - Medical News Today :

Determination Of Structure Of Immune Molecule That Counteracts HIV Strains Advance The Effort To Develop An AIDS Vaccine

In findings that contribute to efforts to design an AIDS vaccine, a team led by Scripps Research Institute scientists has determined the structure of an immune system antibody molecule that effectively acts against most strains of human immunodeficiency virus ( HIV ), the virus that causes AIDS. The study, which is being published in an advance, online issue of the journalProceedings of the National Academy of Sciences (PNAS) during the week of June 1, 2010, illuminates an unusual human antibody called PG16.

http://www.medicalnewstoday.com/articles/190637.php

Genetic Mutation Shown To Trigger Melanoma

Researchers have discovered that a genetic mutation found in some malignant melanomas can initiate development of this most deadly form of skin cancer , according to a study published today in the journal Cancer Research. The gene KRAS was already known to be mutated in about two per cent of malignant melanomas but the new study by The Institute of Cancer Research (ICR) is the first to show that damage to this gene can be the first in a procession of genetic events necessary to trigger

http://www.medicalnewstoday.com/articles/190613.php

Nottingham Research Leads To Blood Test For Early Detection Of Cancer

The University of Nottingham spin-out company, Oncimmune Ltd, has developed a ground breaking blood test which will aid the detection of cancer as much as five years earlier than current testing methods such as mammography and CT scans. Physicians will know the result of their patient's test within one week of sending in a blood sample to Oncimmune. Oncimmune has developed a new technique which replicates the cancer proteins that trigger the body's response to the disease and robotic technology to measure this response. This new technology (immuno-biomarkers) provides a significant advance in how early a cancer may be detected and is likely to change the current paradigm of diagnosis and treatment for most solid cancers such as lung, breast, ovarian, colon and prostate.

http://www.medicalnewstoday.com/articles/190562.php

Prototype Breast Cancer Vaccine Prevents Tumors In Mice

US immunologists have developed a prototype breast cancer vaccine that targets a protein that is only present in breast cells when a woman is lactating or when she has breast cancer: they found it provided protection against breast cancer in mice and suggest it could be developed to protect women against the disease in their post-childbearing years. You can read how lead investigator Dr Vincent Tuohy, and colleagues from the Cleveland Clinic's Lerner Research Institute in Cleveland, Ohio, conducted their research in an online before print issue of their study that appeared inNature Medicine on 30 May.

http://www.medicalnewstoday.com/articles/190399.php

Source - MIT's Technology Review :

Neural Stimulation for Autoimmune Diseases

http://www.technologyreview.com/biomedicine/25440/

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