Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ <http://www.gbpcap.com/> . Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.
Source - EurekAlert - Biology:
Public Release: 5-Jan-2010
Protein linked to leukemia 'bookmarks' highly active genes during cell division <http://www.eurekalert.org/pub_releases/2010-01/cshl-plt010510.php>
Cold Spring Harbor Laboratory scientists have discovered how some epigenetic instructions get stably transferred from one generation of cells to the next. They report that newly formed cells learn which genes need to become highly active right away thanks to a helpful protein that "bookmarks" these genes during the division of their parent cell.
Contact: Hema Bashyam
bashyam@cshl.edu <mailto:bashyam@cshl.edu>
516-367-6822
Cold Spring Harbor Laboratory <http://www.cshl.org/>
Public Release: 5-Jan-2010
Researchers revisit pulmonary arterial hypertension survival <http://www.eurekalert.org/pub_releases/2010-01/uocm-rr010510.php>
Setting out to determine the survival of patients with pulmonary arterial hypertension (PAH), researchers at the University of Chicago Medical Center and their colleagues also discovered that an equation used for more than 20 years to predict survival is outdated. Accordingly, they developed and recently published a new survival prediction equation that will impact clinical practice and the drug development process.
Contact: Greg Borzo
greg.borzo@uchospitals.edu <mailto:greg.borzo@uchospitals.edu>
773-795-0892
University of Chicago Medical Center <http://www.uchospitals.edu/>
Public Release: 5-Jan-2010
Study provides insight into pathway linked to obesity <http://www.eurekalert.org/pub_releases/2010-01/uoi-spi010510.php>
A new study involving the University of Iowa, Mayo Clinic and two other institutions provides insight on weight control, suggesting that a potassium channel critical to survival and stress adaptation can contribute to fat deposition and obesity.
Contact: Becky Soglin
becky-soglin@uiowa.edu <mailto:becky-soglin@uiowa.edu>
319-356-7127
University of Iowa <http://www.uiowa.edu/>
Public Release: 5-Jan-2010
A global breakthrough in the study of a protein linked to the spread of viruses <http://www.eurekalert.org/pub_releases/2010-01/udq-agb010510.php>
Professor Denis Archambault of the Department of Biological Sciences of Université du Québec à Montréal, and doctoral student Andrea Corredor Gomez have made a major discovery in the field of molecular biology. They have unlocked some of the secrets of a viral protein, known as Rev, which is very different from other proteins of the same type studied to date. The results of their research were recently published in the prestigious Journal of Virology.
Contact: Claire Bouchard
bouchard.claire@uqam.ca <mailto:bouchard.claire@uqam.ca>
514-987-3111
Université du Québec à Montréal <http://www.uqam.ca/>
Public Release: 5-Jan-2010
Celebrex inhibited the burden of skin cancer in high-risk patients <http://www.eurekalert.org/pub_releases/2010-01/aafc-cit010410.php>
People with the heritable disorder of the skin called Gorlin syndrome who are genetically predisposed to develop basal cell carcinoma of the skin may have a new chemoprevention therapy on the horizon.
Contact: Tara Yates
tara.yates@aacr.org <mailto:tara.yates@aacr.org>
267-646-0558
American Association for Cancer Research <http://www.aacr.org/>
Public Release: 4-Jan-2010
Experimental drug shows promise against brain, prostate cancers <http://www.eurekalert.org/pub_releases/2010-01/usmc-eds123009.php>
An experimental drug currently being tested against breast and lung cancer shows promise in fighting the brain cancer glioblastoma and prostate cancer, researchers at UT Southwestern Medical Center have found in two preclinical studies.
Contact: Aline McKenzie
aline.mckenzie@utsouthwestern.edu <mailto:aline.mckenzie@utsouthwestern.edu>
214-648-3404
UT Southwestern Medical Center <http://www.swmed.edu/>
Public Release: 4-Jan-2010
MyoD helps stem cells proliferate in response to muscle injury <http://www.eurekalert.org/pub_releases/2010-01/rup-mhs122409.php>
The master regulator of muscle differentiation, MyoD, functions early in myogenesis to help stem cells proliferate in response to muscle injury, according to researchers at Case Western Reserve University. The study appears online Jan. 4 in the Journal of Cell Biology.
Contact: Rita Sullivan
news@rupress.org <mailto:news@rupress.org>
212-327-8603
Rockefeller University Press <http://www.rockefeller.edu/RUPress/>
Public Release: 4-Jan-2010
Gladstone scientists identify target that may inhibit HIV infectivity <http://www.eurekalert.org/pub_releases/2010-01/gi-gsi122309.php>
Scientists at the Gladstone Institute of Virology and Immunology have discovered a new agent that might inhibit the infectivity of HIV. The agent, surfen, impairs the action of a factor in semen that greatly enhances the viral infection. Surfen might be used to supplement current HIV microbicides to greatly reduce HIV transmission during sexual contact
Contact: Valerie Tucker
vtucker@gladstone.ucsf.edu <mailto:vtucker@gladstone.ucsf.edu>
415-734-2019
Gladstone Institutes <http://www.gladstone.ucsf.edu/>
Public Release: 31-Dec-2009
Carbon nanotubes show promise for high-speed genetic sequencing <http://www.eurekalert.org/pub_releases/2009-12/asu-cns122909.php>
In the current issue of Science, Stuart Lindsay, director of Arizona State University's Center for Single Molecule Biophysics at the Biodesign Institute, along with his colleagues, demonstrates the potential of a new DNA sequencing method in which a single-stranded ribbon of DNA is threaded through a carbon nanotube.
Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu <mailto:joseph.caspermeyer@asu.edu>
480-258-8972
Arizona State University <http://www.asu.edu/news>
Source - Science Daily:
Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.
Breast Cancer Screening Should Begin at Age 40, New Recommendations Suggest <http://www.sciencedaily.com/releases/2010/01/100104114555.htm>
January 5, 2010 — The new recommendations from the Society of Breast Imaging and the American College of Radiology on breast cancer screening state that breast cancer screening should begin at age 40 and earlier in ...
http://www.sciencedaily.com/releases/2010/01/100104114555.htm <http://www.sciencedaily.com/releases/2010/01/100104114555.htm>
New Key Factor Identified in the Development of Alzheimer's Disease <http://www.sciencedaily.com/releases/2010/01/100104143503.htm>
January 5, 2010 — A small protein found in the gene- ß -amyloid precursor protein, APP, has been identified as a novel factor for the development of Alzheimer's disease related endosome abnormalities, which have ...
http://www.sciencedaily.com/releases/2010/01/100104143503.htm <http://www.sciencedaily.com/releases/2010/01/100104143503.htm>
Exercise Helps Patients With Peripheral Artery Disease <http://www.sciencedaily.com/releases/2009/12/091202101757.htm>
January 5, 2010 — Peripheral artery disease affects 5 million individuals in the US and is the leading cause of limb amputations. Doctors have long considered exercise to be the single best therapy for PAD, and now a ...
http://www.sciencedaily.com/releases/2009/12/091202101757.htm <http://www.sciencedaily.com/releases/2009/12/091202101757.htm>
Severe Asymptomatic Heart Disease May Accompany Narrowing in Leg Arteries <http://www.sciencedaily.com/releases/2009/12/091201084154.htm>
January 4, 2010 — Results of a randomized, controlled clinical trial reveal that one in five patients with narrowing or blockage in arteries that supply blood to the legs and other parts of the body also have ...
http://www.sciencedaily.com/releases/2009/12/091201084154.htm <http://www.sciencedaily.com/releases/2009/12/091201084154.htm>
Breast Cancer Survival Improves If Herceptin Is Used With Chemotherapy <http://www.sciencedaily.com/releases/2009/12/091212141414.htm>
January 4, 2010 — Using Herceptin with chemotherapy, instead of after, clearly improves treatment of women with HER2+ breast cancer, and should be the new standard of care, says a ...
http://www.sciencedaily.com/releases/2009/12/091212141414.htm <http://www.sciencedaily.com/releases/2009/12/091212141414.htm>
How Ubiquitin Chains Are Added to Cell-Cycle Proteins: May Lead to Targeted Cancer Therapies <http://www.sciencedaily.com/releases/2009/12/091202131627.htm>
January 4, 2010 — Researchers have been able to view in detail, and for the first time, the previously mysterious process by which long chains of a protein called ubiquitin are added by enzymes called ubiquitin ...
http://www.sciencedaily.com/releases/2009/12/091202131627.htm <http://www.sciencedaily.com/releases/2009/12/091202131627.htm>
Dampening CD4+ Immune Cell Function Via the Protein TLR4 <http://www.sciencedaily.com/releases/2010/01/100104210625.htm>
January 4, 2010 — The immune system uses a large number of proteins to sense the presence of microbes, including a family of proteins known as TLRs. The function of TLRs on immune cells known as DCs and macrophages ...
http://www.sciencedaily.com/releases/2010/01/100104210625.htm <http://www.sciencedaily.com/releases/2010/01/100104210625.htm>
Targeting Cancerous Vessels <http://www.sciencedaily.com/releases/2010/01/100104091128.htm>
January 4, 2010 — By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival. The findings are reported online in the Journal of Experimental Medicine ...
http://www.sciencedaily.com/releases/2010/01/100104091128.htm <http://www.sciencedaily.com/releases/2010/01/100104091128.htm>
Imaging Study Shows HIV Particles Assembling Around Genome of Infected Cell <http://www.sciencedaily.com/releases/2009/12/091231154404.htm> January 2, 2010 — HIV is a wily and lethal replicator. In less than 25 years, it's killed more than 25 million people. Scientists are exploring exactly how this virus reproduces because they would like to find a way ...
http://www.sciencedaily.com/releases/2009/12/091231154404.htm <http://www.sciencedaily.com/releases/2009/12/091231154404.htm>
New Research Could Advance Research Field Critical to Personalized Medicine <http://www.sciencedaily.com/releases/2009/12/091229105904.htm>
January 1, 2010 — It's the ultimate goal in the treatment of cancer: tailoring a person's therapy based on his or her genetic makeup. While a lofty goal, scientists are steadily moving forward, rapidly exploiting new ...
http://www.sciencedaily.com/releases/2009/12/091229105904.htm <http://www.sciencedaily.com/releases/2009/12/091229105904.htm>
Source - Health Day:
Health Highlights: Jan. 5, 2010 <http://www.healthday.com/Article.asp?AID=634663>
- Head Blows Don't Cause Brain Damage: Ex-NFL Doctor
- FDR Killed by Melanoma, Authors Say
- Women With Partners Gain More Weight: Study
- Octuplets Doctor Accused of Negligence
Little difference seen in loss of quality-of-life years between the two, study finds
Stem Cells Likely to Help Genetic Disorders First <http://www.healthday.com/Article.asp?AID=629833>
Drugs developed without animal testing could be one result, some predict
Clinical Trials Update: Jan. 5, 2010 <http://www.healthday.com/Article.asp?AID=634664>
- Diabetic Gastroparesis
- COPD (Chronic Obstructive Pulmonary Disease)
- Influenza
FDA drug approvals mostly flat in 2009 <http://us.rd.yahoo.com/finance/industry/news/mostpop/*http:/biz.yahoo.com/ap/100105/us_fda_2009_drug_approvals.html?.v=7> - AP - 1 hour, 3 minutes ago
New drugs cleared by the Food and Drug Administration last year kept pace with 2008, suggesting a much-touted push for drug safety has not slowed down approvals.
Source - Google Health News:
Zinc Finger Techniques Could Be Gene Therapy Breakthrough <http://www.google.com/url?sa=X&q=http://www.bio-itworld.com/els/2010/1/5/zinc-fingers.html&ct=ga&cd=qLhVnVIO5Ic&usg=AFQjCNG-vtF5IQ2oeatIjvZJOfDCqjnQHQ>
Bio-IT World
January 5, 2010 | Scientists at the University of Pennsylvania have used a new technique to to disrupt a gene in T cells. The results are in clincal trials ...
2020 vision: where will we be in a decade's time? <http://www.google.com/url?sa=X&q=http://www.telegraph.co.uk/lifestyle/6917389/2020-vision-where-will-we-be-in-a-decades-time.html&ct=ga&cd=QQF6hEky7pk&usg=AFQjCNEz5nq4blI_U82yEdqpQZfnjEc68A>
Telegraph.co.uk
Ten years ago, I would have said that by 2010 gene therapy would be a standard medical treatment – and I would have been wrong. Two years ago, my prediction ...
Source - Medical News Today:
Targeting Cancerous Vessels <http://www.medicalnewstoday.com/articles/175121.php>
By lowering the level of a neuronal protein, researchers halted the growth of blood vessels that tumors rely on for survival. The findings are reported online in the Journal of Experimental Medicine. Formerly known for its effects on neuronal growth, the team found that the protein {delta}-catenin is also produced by cells in human blood vessels. By diminishing {delta}-catenin expression, the team disrupted vessel development, or angiogenesis, associated with inflammation in tumors and wounds. As expected, samples of human lung tumors expressed more {delta}-catenin than the surrounding tissues. And normal angiogenesis remained the same regardless of {delta}-catenin.
http://www.medicalnewstoday.com/articles/175121.php <http://www.medicalnewstoday.com/articles/175121.php>
Discovery Targets, Kills Tumors <http://www.medicalnewstoday.com/articles/175039.php>
A team of researchers in California and Massachusetts has developed a "cocktail" of different nanometer-sized particles that work in concert within the bloodstream to locate, adhere to and kill cancerous tumors. "This study represents the first example of the benefits of employing a cooperative nanosystem to fight cancer <http://www.medicalnewstoday.com/info/cancer-oncology/whatiscancer.php> ," said Michael Sailor, a professor of chemistry and biochemistry at the University of California, San Diego and the primary author of a paper describing the results, which is being published in a forthcoming issue of the Proceedings of the National Academy of Sciences. An early online version of the paper appeared last week.
http://www.medicalnewstoday.com/articles/175039.php <http://www.medicalnewstoday.com/articles/175039.php>
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