Tuesday, June 23, 2009

GBP Health / Biotech News 06-23-2009

Since August, 2005, this news digest has been a complimentary service of GBP Capital, a private equity firm investing in early to mid-stage life science companies. See www.gbpcap.com. The digest is published two to four days a week. If you have colleagues who would be interested in receiving this digest by email, they can be added to the list at: http://www.gbpcap.com/ .  Also, the complete history of the entire content of all news articles in our digests since August, 2005 is searchable with Google's enterprise search engine at the same site.   

Source - EurekAlert – Biology

Public Release: 23-Jun-2009
Cancer Research
Biomarkers predict brain tumor's response to therapy
A report in Cancer Research, a journal of the American Association for Cancer Research, highlights a new biomarker that may be useful in identifying patients with recurrent glioblastoma, or brain tumors, who would respond better to anti-vascular endothelial growth factor therapy, specifically cediranib.
Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research

Public Release: 23-Jun-2009
Molecular Psychiatry
ADHD genes found, known to play roles in neurodevelopment
Pediatric researchers have identified hundreds of gene variations that occur more frequently in children with attention-deficit hyperactivity disorder than in children without ADHD. Many of those genes were already known to be important for learning, behavior, brain function and neurodevelopment, but had not been previously associated with ADHD.
National Institutes of Health
Contact: Juliann Walsh
Walshj1@email.chop.edu
267-426-6054
Children's Hospital of Philadelphia

Public Release: 23-Jun-2009
Journal of Neurochemistry
New research discovers link between smoking and brain damage
New research which suggests a direct link between smoking and brain damage will be published in the July issue of the Journal of Neurochemistry.
Contact: Ben Norman
Benorman@wiley.com
44-124-377-0375
Wiley-Blackwell
 
Public Release: 23-Jun-2009
Zoonoses and Public Health
Study shows Chronix technology using serum DNA can identify early presence of disease
A new publication confirms the potential diagnostic and prognostic utility of using circulating fragments of DNA, known as serum DNA, to detect early stage disease. Chronix has developed technology that can find and identify serum DNA sequences, enabling very early detection of an underlying disease state or of a change in response to treatment. Using Chronix technology, researchers identified specific signature sequences in serum DNA before clinical symptoms appeared in animals experimentally infected with BSE.
Contact: Barbara Lindheim
212-918-4650
BioCom Partners


Public Release: 23-Jun-2009
Experimental Biology and Medicine
Children's Hospital Oakland scientists first to discover new source for harvesting stem cells
A groundbreaking study conducted by Children's Hospital & Research Center Oakland is the first to reveal a new avenue for harvesting stem cells from a woman's placenta, or more specifically the discarded placentas of healthy newborns. The study also finds there are far more stem cells in placentas than in umbilical cord blood, and they can be safely extracted for transplantation.
Contact: Diana Yee
dyee@mail.cho.org
510-428-3120
Children's Hospital & Research Center at Oakland

Public Release: 22-Jun-2009
Proceedings of the National Academy of Sciences
Bioengineers develop a microfabricated device to measure cellular forces during tissue development
A Penn-led collaboration studying the physical forces generated by cells has created a tiny micron-sized device that measures and manipulates cellular forces as assemblies of living cells reorganize themselves into tissues.
National Institutes of Health, ARO Multidisciplinary University Research Initiative, University of Pennsylvania, US Department of Energy, National Science Foundation
Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania

Source - Science Daily:

Please note: Due to the format restrictions of Science Daily articles, you must click on the URL (web address) below the article summary, rather than the article title.

Tumor Suppressor Gene In Flies May Provide Insights For Human Brain Tumors
June 23, 2009
— In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes ...
http://www.sciencedaily.com/releases/2009/06/090622112802.htm
 
Cancer Researchers Develop Model That May Help Identify Cancer Stem Cells
June 23, 2009
— Researchers, on a quest to find lung cancer stem cells, have developed a unique model to allow further investigation into the cells that many believe may be at the root of all lung ...
http://www.sciencedaily.com/releases/2009/06/090616103323.htm
 
New Research Unravels How Proteins Help Repair DNA
June 23, 2009
— A person's DNA is often damaged by a number of different chemical contaminants, and if not repaired properly, it can lead to the development of cancer and other diseases. Researchers have now ...
http://www.sciencedaily.com/releases/2009/06/090615171519.htm
 
Blocking A Muscle Growth-limiting Hormone Protects Against Obesity And Atherosclerosis
June 23, 2009
— Knockout of myostatin, a growth factor that limits muscle growth, can decrease body fat and promote resistance against developing atherosclerosis, or "hardening" of the arteries, according to a new ...
http://www.sciencedaily.com/releases/2009/06/090611112557.htm
 
Curb A Cancer's Deadliness? Potent Metastasis Inhibitor Identified
June 23, 2009
— Researchers have isolated a potent metastasis inhibitor produced by tumor cells, one that could potentially be harnessed as a cancer treatment. The protein, prosaposin, reduced metastases by 80 ...
http://www.sciencedaily.com/releases/2009/06/090622171406.htm
 
Cancer Is Second Most Frequent Cause Of Death In Individuals With Schizophrenia
June 23, 2009
— People with schizophrenia die from cancer four times as often as people in the general population. The study's results suggest that extra efforts should be made to improve cancer prevention and early ...
http://www.sciencedaily.com/releases/2009/06/090622064815.htm
 
Melatonin: The Fountain Of Youth?
June 23, 2009
— Melatonin can slow down the effects of aging. Scientists have found that a treatment based on melatonin can delay the first signs of aging in a small ...
http://www.sciencedaily.com/releases/2009/06/090622064807.htm
 
Non-invasive Brain Surgery: Successful Neurosurgery With Transcranial MR-guided High-Intensity Focused Ultrasound
June 23, 2009
— Medical researchers have achieved a world first break through in MR-guided, non-invasive neurosurgery. Ten patients have been successfully treated by means of transcranial high-intensity focused ...
http://www.sciencedaily.com/releases/2009/06/090622064711.htm
 
Mouse Model Of Parkinson's Reproduces Nonmotor Symptoms
June 23, 2009
— Nonmotor symptoms of Parkinson's include digestive and sleep problems, loss of sense of smell and depression. A mouse with a mutation in a gene responsible for packaging neurotransmitters like ...
http://www.sciencedaily.com/releases/2009/06/090623091123.htm
 
Student’s Design Helps Piece Together Parts Of The Alzheimer’s Puzzle
June 23, 2009
— Extensive research in care homes across South East England has prompted a student to design a jigsaw puzzle especially for people with Alzheimer's disease and other forms of dementia. The puzzle, ...
http://www.sciencedaily.com/releases/2009/06/090623090659.htm
 
Survivors Of Childhood Central Nervous System Cancer Face Persistent Risks As Adults
June 22, 2009
— Long-term survivors of childhood central nervous system malignancies remain at risk for death and are at increasing risk for developing subsequent cancers and chronic medical conditions over time, ...
http://www.sciencedaily.com/releases/2009/06/090617191335.htm
 
Engineered Pig Stem Cells Bridge The Mouse-human Gap
June 22, 2009
— Researchers have created a line of embryonic-like stem cells from adult pigs. As pigs are large animals with a physiology very similar to humans, this work provides a valuable model to study the ...
http://www.sciencedaily.com/releases/2009/06/090604095125.htm
 
New Lasers Drive Powerful Applications
June 22, 2009
— Telecoms, healthcare and display technology will be the major beneficiaries of a new generation of semiconductor lasers developed in a massive research effort. Better cancer treatment, wider ...
http://www.sciencedaily.com/releases/2009/06/090622194229.htm
 
Targeting Helpers Of Heat Shock Proteins Could Help Treat Cancer, Cardiovascular Disease
June 22, 2009
— Dissecting how heat shock protein 90 gets steroid receptors into shape to use hormones like estrogen and testosterone could lead to targeted therapies for hormone-driven cancers, such as breast and ...
http://www.sciencedaily.com/releases/2009/06/090622112800.htm
 
Does Study Design Influence Clinical Outcome?
June 22, 2009
— Response and remission rates to antidepressants are significantly affected by study type and duration. Clinicians and researchers must consider the study design when interpreting and designing RCTs ...
http://www.sciencedaily.com/releases/2009/06/090622064703.htm
 
Punching Holes Into Herpes Viruses
June 20, 2009
— Scientists have completed the first description of the mechanics of so-called nuclear herpes virus ...
http://www.sciencedaily.com/releases/2009/06/090611194127.htm
 
Is Nanotechnology Safe? Interactions Between Nanomaterials And Biological Systems Explored
June 20, 2009
— Tremendous growth in the development of nanomaterials with enhanced performance characteristics which are being used for commercial and medical applications prompts researchers to take a proactive ...
http://www.sciencedaily.com/releases/2009/06/090619152134.htm
 
New Vaccination Strategy May Protect Against Both Lethal 1918 And H5N1 Influenza Viruses
June 20, 2009
— A new study suggests that vaccination with 1918 H1N1 influenza virus-like particles not only protected mice and ferrets against the lethal 1918 influenza virus, but also displayed cross-reactive ...
http://www.sciencedaily.com/releases/2009/06/090619112429.htm

Source - Health Day:

Health Highlights: June 23, 2009
  • FDA Warns About Salmonella-Tainted Pistachios
  • Americans Now Have Higher Out-of-Pocket Costs: Report
  • Nutrient May Protect Babies' Brains From Alcohol
  • U.S. Study Will Target Vitamin D, Fish Oil
Eat Well, Live Longer
Age-old advice to eat healthy pays off in longevity, study finds.
Clinical Trials Update: June 23, 2009
  • Conjunctivitis, Bacterial
  • Neuropathy
  • Bladder Disorders
  • High Blood Pressure (Hypertension)
  • Type 2 Diabetes and Weight Loss
  • High Cholesterol
HIV 'Atlas' Shows Virus Targeting Minorities
80% of U.S. cases occur in just 20% of counties, report finds
Promising Therapy for Prostate Cancer
Experimental drug beat back inoperable cancer in two patients, study claims

Clinical Trials Update: June 22, 2009
  • Osteoarthritis of the Hip
  • Chronic Obstructive Pulmonary Disease
  • Osteoarthritis of the Knee or Hip
  • Staphylococcal Infections
  • Attention Deficit/Hyperactivity Disorder (ADHD - Adults)
  • Alzheimer's Disease

Source - Yahoo Biotech News:

 
Advanced Life Sciences' Restanza(TM) Shows 100% Survival In Confirmatory Anthrax Study - PR Newswire - Tue 9:00 am ET
Advanced Life Sciences Holdings, Inc. , today announced that a second non-human primate study involving its novel, once-a-day, oral antibiotic Restanza , showed that a 14-day course of Restanza achieved a 100% survival rate against an inhaled lethal dose of anthrax.
 
Medarex shares jump on report on just 2 patients  - AP - Mon 2:48 pm ET
Shares of drug developer Medarex Inc. jumped Monday after an unusual report that two men in a study of its experimental prostate cancer drug had their tumors shrink dramatically. The report gave no information on how other men in the study fared.
 
Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial  - PR Newswire - Mon 1:30 am ET
 
Source - Google Health News:


Targeted Genetics Announces Continued Clinical Study at University ...
Market Wire (press release) - USA
This revised protocol was reviewed and approved by the Gene Therapy Advisory Committee, the Medicines and Healthcare Products Regulatory Agency, ...
 
Dog undergoing gene therapy may save at risk children
Examiner.com - USA
The dog being treated at the University of Florida underwent gene therapy when it was first born and responded positively for the first several weeks, ...
 
Gene therapy gets under the skin
ETH Life - Switzerland
Vaseline, a known molecule from apples and a gene network encapsulated in algal gelatin are the components of a possible gene therapy which literally gets ...
 
New Targeted Therapy Could Eradicate HIV, Study Finds
Kaiser Family Foundation - Menlo Park,CA,USA
Researchers from Oregon State University's Vaccine and Gene Therapy Institute (VGTI) Florida and the University of Montreal say they have discovered a ...

Source - Medical News Today:
 

The Alliance For The Advancement Of Adult Stem Cell Therapy And Research Announces Successful Treatment Of End-Stage Heart Disease With Stem Cells
Zannos Grekos, MD, Associate Clinical Professor at Nova Southeastern University, has announced six month follow-up results for a patient treated with adult stem cells  in a clinical study of idiopathic dilated cardiomyopathy. The clinical study is a collaborative effort among physicians at Regenocyte Therapeutic, an American stem cell therapy clinic; researchers and scientists from Theravitae, a biotechnology company from Israel; and physicians from the American Institute for Regenerative Medicine, Dominican Republic.  Leonard Narracci, 71 from Venice, Florida, underwent the adult stem cell therapy in October 2008. Since being diagnosed with idiopathic dilated cardiomyopathy and congestive heart failure, Narracci's ejection fraction was severely reduced at 18% (with normal being over 55%). Within three months of the treatment, his ejection fraction improved to 40% and it is now at 51%.
http://www.medicalnewstoday.com/articles/155014.php
 
New Online Tool Maps HIV, AIDS Prevalence By County, Other Statistics
The National Minority Quality Forum (NMQF) today launched an online tool  that maps the prevalence of HIV and AIDS by county, age, gender and ethnicity in all 50 states, Washington, D.C., Puerto Rico and the U.S. Virgin Islands, the San Francisco Chronicle  reports. The HIV/AIDS Atlas is based on 2006 data collected from states and cross-checked with CDC data. The NMQF partnered with George Washington University's School of Public Health and Health Services to collect and analyze the data. Gary Puckrein, chief executive officer of NMQF, said the new tool will help improve data collection and analysis, prevention initiatives, early diagnosis and routine testing efforts in areas most affected by HIV/AIDS (Colliver, San Francisco Chronicle, 6/21).
http://www.medicalnewstoday.com/articles/154953.php
 
Multiple Sclerosis: Hope Through New Oral Therapeutics
"The immunomodulating and immunosuppressive therapies for multiple sclerosis available today are only partially effective. We need a better use of the existing therapies - inter alia through early treatment and innovative approaches - in order to more efficiently help our patients," says Professor Giancarlo Comi of Milan, Italy, Chairperson of the meeting of the European Neurological Society (ENS) currently held in his home town. This major meeting in European neurology gathers more than 2,900 experts from all over the world. Professor Comi: "One interesting development involves new drugs highly active that can be taken orally."   More than 400,000 people in Europe suffer from multiple sclerosis (MS), the most common neurological disease leading to permanent disability in young adults. MS attacks the central nervous system and is considered an auto-immune disease, but other possible causes are also under discussion. "Multiple sclerosis is still not curable. A number of new findings have been made in recent years with regard to the origins of the disease and new therapeutic strategies," says Professor Comi. "These new insights can help us to mitigate the course of the disease and delay the development of permanent disabilities. Moreover some new treatments which will be available soon will enhance the possibility to control the disease evolution, opening new positive perspectives for patients."
http://www.medicalnewstoday.com/articles/154917.php
 
Stem Cell Discovery May Bring Tissue Repair Closer
The goal of creating adult blood stem cells  from human embryos to prepare a patient for tissue and organ transplant has been brought a step closer by research carried out at the MRC Molecular Haematology Unit at Oxford University.   Blood, or haematopoietic, stem cells (HSCs), are a type of adult stem cell that can produce several different types of blood cell, including those of the immune system that are involved in tissue rejection. Scientists have so far been unable to generate HSCs from embryonic stem cells, largely because they have not known how the embryo makes these cells.
http://www.medicalnewstoday.com/articles/154864.php
 
Covidien Features New Devices For Minimally Invasive Surgery And Soft Tissue Repair At ASMBS 2009
Covidien (NYSE: COV), a leading global provider of healthcare products, will showcase a number of its most recent innovations in minimally invasive surgery (MIS) and soft tissue repair at the American Society for Metabolic & Bariatric Surgery (ASMBS) annual meeting on June 21-26, 2009, in Grapevine, Texas. These state-of-the-art innovations underscore Covidien's commitment to working in partnership with the surgical community to develop surgical instruments designed to optimize patient outcomes.   A number of prominent surgeons also will address key industry issues at the Covidien exhibit, including sleeve gastrectomy, the impact of bariatric surgery on patients with Type 2 diabetes , Allergan LAP-BAND AP® Adjustable Gastric Banding System and the next generation of MIS technology.
http://www.medicalnewstoday.com/articles/154822.php

Source - MIT's Technology Review:
 

Search Me
http://www.technologyreview.com/web/22834/?nlid=2123
 
A Better Fit for Hearing Aids
http://www.technologyreview.com/biomedicine/22905/
 
New publications, experiments and breakthroughs in biomedicine--and what they mean.
http://www.technologyreview.com/biomedicine/22835/
 
  

No comments:

Post a Comment

Note: Only a member of this blog may post a comment.