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Journal of NeuroscienceCaltech researchers show efficacy of gene therapy in mouse models of Huntington's disease
Researchers at the California Institute of Technology have shown that a highly specific intrabody (an antibody fragment that works against a target inside a cell) is capable of stalling the development of Huntington's disease in a variety of mouse models. "Gene therapy in these models successfully attenuated the symptoms of Huntington's disease and increased life span," notes Paul Patterson, the Anne P. and Benjamin F. Biaggini Professor of Biological Sciences.
Hereditary Disease Foundation, NIH/National Institute of Neurological Disorders and Stroke FASEB JournalScientists discover influenza's Achilles heel: Antioxidants
As the nation copes with a shortage of vaccines for H1N1 influenza, a team of Alabama researchers have raised hopes that they have found an Achilles' heel for all strains of the flu -- antioxidants. In an article appearing in the November 2009 print issue of the FASEB Journal they show that antioxidants -- the same substances found in plant-based foods -- might hold the key in preventing the flu virus from wreaking havoc on our lungs.
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Cancer ResearchUT Southwestern researchers use drug-radiation combo to eradicate lung cancer
Researchers at UT Southwestern Medical Center have eliminated non-small cell lung cancer in mice by using an investigative drug called BEZ235 in combination with low-dose radiation.
National Institutes of Health, American Cancer Society, Concern Foundation, Gibson Foundation, Leukemia of Texas, US Department of Energy, American Italian Cancer FoundationContact: Connie Piloto
Connie.piloto@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Cell TransplantationPlacental precursor stem cells require testosterone-free environment to survive
Trophoblast stem cells, found in the layer of peripheral embryonic stem cells from which the placenta is formed, are thought to exhibit "immune privilege" that aids cell survivability and is potentially beneficial for cell and gene therapies. Survivability of TSCs has been thought to require the presence of ovarian hormones. This study, however, demonstrates that it is the absence of male hormones, rather than the presence of female hormones, that allows extended transplanted cell survivability.
Roche Organ Transplantation Research Foundationbbinas@hanyang.ac.kr
Cell Transplantation Center of Excellence for Aging and Brain Repair
Cell TransplantationResearchers find brain cell transplants help repair neural damage
This study aimed at determining whether autografted cells derived from primate cortical gray matter, cultured for one month and re-implanted in the caudate nucleus of dopamine depleted primates, effectively survived and migrated. When transplanted, autologous cells, derived from the most dopamine depleted region of the caudate nucleus, migrated, re-implanted into the right caudate nucleus, and migrated through the corpus callosum to the contralateral striatum. Re-implanted cells survived at rate of 50 percent four months post-implantation.
Foundation Swiss Parkinson, Axion Research Foundation, St. Kitts Biomedical Research FoundationContact: Dr. Jean-Francoise Brunet
Jean-Francoise.Brunet@chuv.ch
Cell Transplantation Center of Excellence for Aging and Brain Repair
Cell'Moonlighting' molecules discovered
Since the completion of the human genome sequence, a question has baffled researchers studying gene control: How is it that humans, being far more complex than the lowly yeast, do not proportionally contain in our genome significantly more gene-control proteins?
National Institutes of Health, NIH/National Eye Institute, W. M. Keck Foundation Distinguished Young Investigator in Medical Research Award, Ruth and Milton Steinbach Fund, private donorsContact: Audrey Huang
audrey@jhmi.edu
410-614-5105
Johns Hopkins Medical Institutions
ScienceU-M study uncovers key to how 'triggering event' in cancer occurs
Researchers at the University of Michigan Comprehensive Cancer Center have discovered what leads to two genes fusing together, a phenomenon that has been shown to cause prostate cancer to develop.
National Institutes of Health, US Department of Defense ScienceNew model may help scientists better predict and prevent influenza outbreaks
A new study by an international team of researchers, led by assistant professor Andrew W. Park, who holds a joint appointment in the University of Georgia Odum School of Ecology and in the College of Veterinary Medicine, may make their task a little easier. The study breaks ground by working across scales and linking sub-molecular changes in the influenza virus to the likelihood of influenza outbreaks.
Contact: Sam Fahmy
sfahmy@uga.edu
706-542-5361
University of Georgia
Source - Science Daily:
October 30, 2009 — A study aimed at determining whether autografted cells derived from primate cortical gray matter, cultured for one month and re-implanted in the caudate nucleus of dopamine depleted primates, ...
Helper T Cell's Effect Raises Possibility Of Cellular Therapy, Vaccine Development
October 30, 2009 — A specific type of T helper cell awakens the immune system to the stealthy threat of cancer and triggers an attack of killer T cells custom-made to destroy the tumors, scientists ...
Possible Link Between IBD Therapy And Skin Cancer, Study Reveals
October 30, 2009 — Findings from a new retrospective cohort study indicate that patients with inflammatory bowel disease, especially those receiving the thiopurine class of medications to treat IBD, may be at risk for ...
Stem Cell Therapy May Offer Hope For Acute Lung Injury
October 29, 2009 — Researchers have shown that adult stem cells from bone marrow can prevent acute lung injury in a mouse model of the ...
Triple-combo Drug Shows Promise Against Antiviral-resistant H1N1
October 29, 2009 — An experimental drug cocktail that includes three prescriptions now widely available offers the best hope in developing a single agent to treat drug-resistant H1N1 swine flu, says a virology ...
Drug-radiation Combo Eradicates Lung Cancer In Mice
October 29, 2009 — Researchers have eliminated non-small cell lung cancer in mice by using an investigative drug called BEZ235 in combination with low-dose ...
Epilepsy Drugs Could Treat Alzheimer's And Parkinson's
October 29, 2009 — Researchers have discovered a potential new function for anti-epileptic drugs in treating neurodegenerative disorders such as Alzheimer's and Parkinson's disease. The study found that neurons in the ...
Dendritic Cells Spark Smoldering Inflammation In Smokers' Lungs
October 28, 2009 — Inflammation still ravages the lungs of some smokers years after they quit the habit. What sparks that smoldering destruction remained a mystery until researchers found that certain dendritic cells ...
Cancer: New Explanation Of 'Asian Paradox'
October 28, 2009 — There is abundant evidence of an association between Helicobacter pylori chronic infection and gastric cancer. The incidence of gastric cancer is much higher in
http://www.sciencedaily.com/releases/2009/10/091028112615.htm
Health Highlights: Oct. 30, 2009
Almost 6 Million U.S. Cases of Swine Flu in First Few Months
CDC says H1N1 may be tied to 21,000 hospitalizations during that time
Source - Yahoo Biotech News:
Idenix Pharmaceuticals Inc. says its partner Novartis AG will not move ahead with optioning a license to a potential hepatitis C drug.
MedImmune announced today it will present four abstracts at the 47th Annual Meeting of Infectious Disease Society of America being held here October 29 through November 1, 2009.
TopNews
The study has shown that vision of these people can be restored with the help of gene therapy. Leber's congenital amaurosis (LCA) is a condition, ...
The Canadian Press
The mice were then exposed to the highly lethal H5N1 virus. The vaccinated mice died but the mice that had been previously infected with H3N2 suffered ...
Los Angeles Times
(Associated Press / October 28, 2009) By Thomas H. Maugh II A new gene therapy procedure to restore function in lungs damaged during harvesting from donors ...
Medscape
... the greatest benefit of the vaccine may be the immunity that it yields to future, more deadly influenza strains: "If H1N1 recombines with H5N1 picking ...
The American Society for Radiation Oncology (ASTRO) will host four news briefings with accompanying live webcasts on the top cancer research papers from its 51st Annual Meeting.
High Definition Colonoscopy Detects More Polyps
High-definition (HD) colonoscopy is much more sensitive than standard colonoscopy in finding polyps that could morph into cancer, say researchers at the Mayo Clinic campus in
http://www.medicalnewstoday.com/articles/169094.php
http://www.technologyreview.com/biomedicine/23822/
Tiny Devices Use Light to Grab Cells
http://www.technologyreview.com/biomedicine/23791/
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